Transcription Factor

Accessions: gcm (DrosophilaTF 1.1), T086806_1.02 (CISBP 1.02), Q27403 (JASPAR 2024)
Names: GCM_DROME, Protein glide, Transcription factor glial cells missing, gcm, T086806_1.02;
Organisms: Drosophila melanogaster
Libraries: DrosophilaTF 1.1 1, CISBP 1.02 2, JASPAR 2024 3
1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed]
2 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q27403
Notes: family:GCM
Length: 504
Pfam Domains: 46-187 GCM motif protein
Sequence:
(in bold interface residues)
1 MVLNGMPITMPVPMPVPMPVPSPPATKSRVAIDWDINDSKMPSVGEFDDFNDWSNGHCRL 60
61 IYSVQSDEARKHASGWAMRNTNNHNVNILKKSCLGVLLCSAKCKLPNGASVHLRPAICDK 120
121 ARRKQQGKQCPNRNCNGRLEIQACRGHCGYPVTHFWRRDGNGIYFQAKGTHDHPRPEAKG 180
181 STEARRLLAGGRRVRSLAVMLARESALSDKLSSLRPTKRQAKTQSIQESKRRRMGASDVL 240
241 ETKQELVVPPTTYLPTSTPTHSTNFNQSQGSYVPAGQGSVISQWNREIHYETEDPCYANG 300
301 MYSYDMLHSPLSAHSSTGSYYQENKPQQLQHSQYQQQLSPQQHVPVSYDPSQPISSSLQC 360
361 GMPSYEICDDTSSLTSSSGYCSEDYGYYNGYLPNSLDVSNGSQSQNLSQDASFYTTSSEI 420
421 FSVFESTLNGGGTSGVDLIYDEATAYQQHQQQGTFPHLTNYQQEPQDQMQSADYYYSNTG 480
481 VDNSWNIQMDATYHPVNSTDPIYC
Interface Residues: 80, 81, 82, 84, 117, 154, 155, 157, 166, 170
3D-footprint Homologues: 1odh_A, 4hc9_A
Binding Motifs: gcm ATGCGGGy
M2560_1.02 wakATGCGGGyhb
MA1840.1 ccrCCCGCATmyw
MA1840.2 CCCGCAT
Binding Sites: gcm_1
gcm_10
gcm_11
gcm_12
gcm_13
gcm_14
gcm_15
gcm_16
gcm_17
gcm_18
gcm_19
gcm_2
gcm_20
gcm_21
gcm_22
gcm_23
gcm_24
gcm_25
gcm_26
gcm_27
gcm_28
gcm_29
gcm_3
gcm_30
gcm_31
gcm_32
gcm_33
gcm_34
gcm_35
gcm_36
gcm_37
gcm_38
gcm_39
gcm_4
gcm_40
gcm_41
gcm_42
gcm_43
gcm_44
gcm_45
gcm_46
gcm_47
gcm_48
gcm_5
gcm_6
gcm_7
gcm_8
gcm_9
MA1840.1.1
MA1840.1.10 / MA1840.1.18
MA1840.1.11 / MA1840.1.20
MA1840.1.12
MA1840.1.13
MA1840.1.14
MA1840.1.15
MA1840.1.16
MA1840.1.17
MA1840.1.18
MA1840.1.19
MA1840.1.2
MA1840.1.20
MA1840.1.3 / MA1840.1.6
MA1840.1.4 / MA1840.1.7
MA1840.1.5 / MA1840.1.9
MA1840.1.10 / MA1840.1.6
MA1840.1.13 / MA1840.1.7
MA1840.1.14 / MA1840.1.8
MA1840.1.9
MA1840.2.1
MA1840.2.16
MA1840.1.11
MA1840.1.12
MA1840.1.15
MA1840.1.16
MA1840.1.17
MA1840.1.19
MA1840.1.3
MA1840.1.4
MA1840.1.5
MA1840.1.8
MA1840.2.10 / MA1840.2.13 / MA1840.2.14 / MA1840.2.19 / MA1840.2.5 / MA1840.2.8
MA1840.2.11
MA1840.2.12
MA1840.2.15 / MA1840.2.2
MA1840.2.17 / MA1840.2.20 / MA1840.2.3 / MA1840.2.4 / MA1840.2.7
MA1840.2.18
MA1840.2.6
MA1840.2.9
Publications: Akiyama Y., Hosoya T., Poole A. M., Hotta Y. The gcm-motif: a novel DNA-binding motif conserved in Drosophila and mammals. Proc. Natl. Acad. Sci. USA 93:14912-14916 (1996). [Pubmed]

Schreiber J, Enderich J, Wegner M. Structural requirements for DNA binding of GCM proteins. Nucleic Acids Res 26:2337-43 (1998). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.