Transcription Factor
| Accessions: | RUNX1_HUMAN (HOCOMOCO 10), Q01196 (JASPAR 2024) |
| Names: | Acute myeloid leukemia 1 protein, CBF-alpha-2, Core-binding factor subunit alpha-2, Oncogene AML-1, PEA2-alpha B, PEBP2-alpha B, Polyomavirus enhancer-binding protein 2 alpha B subunit, Runt-related transcription factor 1, RUNX1_HUMAN, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core-binding factor alpha B subunit |
| Organisms: | Homo sapiens, Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 453 |
| Pfam Domains: | 49-182 Runt domain 359-453 Runx inhibition domain |
| Sequence: (in bold interface residues) | 1 MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPG 60 61 ELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNA 120 121 TAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHR 180 181 QKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQM 240 241 QDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDL 300 301 TAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPG 360 361 SSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSALLNPSLP 420 421 NQSDVVEAEGSHSNSPTNMAPSARLEEAVWRPY |
| Interface Residues: | 80, 142, 170, 171, 174, 177 |
| 3D-footprint Homologues: | 4l18_E, 6vg8_D, 3wts_A, 6vgd_D, 4l0y_A |
| Binding Motifs: | MA0002.2 ktyTGTGGttw RUNX1_HUMAN.H10MO.A|M01490 byTGTGGTTwk MA0002.1 wwyTGyGGTww MA0002.3 yTGTGGttw |
| Binding Sites: | MA0002.1.1 MA0002.1.10 MA0002.1.11 MA0002.1.12 MA0002.1.13 MA0002.1.14 MA0002.1.15 MA0002.1.16 MA0002.1.17 MA0002.1.18 MA0002.1.19 MA0002.1.2 MA0002.1.20 MA0002.1.3 MA0002.1.4 MA0002.1.5 MA0002.1.6 MA0002.1.7 MA0002.1.8 MA0002.1.9 |
| Publications: | Meyers S., Downing J. R., Hiebert S. W. Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins:the runt homology domain is required for DNA binding and protein-protein interactions. Mol. Cell. Biol. 13:6336-6345 (1993). [Pubmed] |
| Related annotations: | PaperBLAST |
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