Transcription Factor
Accessions: | P53_HUMAN (HOCOMOCO 10), P04637 (JASPAR 2024) |
Names: | Antigen NY-CO-13, Cellular tumor antigen p53, P53_HUMAN, Phosphoprotein p53, Tumor suppressor p53 |
Organisms: | Homo sapiens |
Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Length: | 393 |
Pfam Domains: | 6-29 P53 transactivation motif 95-288 P53 DNA-binding domain 318-358 P53 tetramerisation motif |
Sequence: (in bold interface residues) | 1 MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP 60 61 DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK 120 121 SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE 180 181 RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS 240 241 SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP 300 301 PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG 360 361 GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD |
Interface Residues: | 120, 121, 248, 276, 277, 280, 281 |
3D-footprint Homologues: | 7xzx_N, 3q05_B, 7xzz_N, 5kbd_B, 3exj_A, 3qyn_C |
Binding Motifs: | MA0106.3 rACATGyCcgGrCATGTy MA0106.2 rCATGycCarRCATG P53_HUMAN.H10MO.B|M01411 rgrCATGyytGgrCATGycy MA0106.1 msGRACATGyCCGGGCATGT |
Binding Sites: | MA0106.1.1 MA0106.1.10 MA0106.1.11 MA0106.1.12 MA0106.1.13 MA0106.1.14 MA0106.1.15 MA0106.1.16 MA0106.1.17 MA0106.1.2 MA0106.1.3 MA0106.1.4 MA0106.1.5 MA0106.1.6 MA0106.1.7 MA0106.1.8 MA0106.1.9 MA0106.2.1 MA0106.2.10 MA0106.2.11 MA0106.2.12 MA0106.2.13 MA0106.2.14 MA0106.2.15 MA0106.2.16 MA0106.2.17 MA0106.2.18 MA0106.2.19 MA0106.2.2 MA0106.2.20 MA0106.2.3 MA0106.2.4 MA0106.2.5 MA0106.2.6 MA0106.2.7 MA0106.2.8 MA0106.2.9 |
Publications: | Funk W. D., Pak D. T., Karas R. H., Wright W. E., Shay J. W. A transcriptionally active DNA-binding site for human p53 protein complexes. Mol. Cell. Biol. 12:2866-2871 (1992). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.