Transcription Factor
| Accessions: | BACH1_HUMAN (HOCOMOCO 10), O14867 (JASPAR 2024) |
| Names: | BACH1_HUMAN, BTB and CNC homolog 1, HA2303, Transcription regulator protein BACH1 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 736 |
| Pfam Domains: | 24-127 BTB/POZ domain 561-608 bZIP transcription factor 562-602 Basic region leucine zipper |
| Sequence: (in bold interface residues) | 1 MSLSENSVFAYESSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFH 60 61 SRIVGQADGELNITLPEEVTVKGFEPLIQFAYTAKLILSKENVDEVCKCVEFLSVHNIEE 120 121 SCFQFLKFKFLDSTADQQECPRKKCFSSHCQKTDLKLSLLDQRDLETDEVEEFLENKNVQ 180 181 TPQCKLRRYQGNAKASPPLQDSASQTYESMCLEKDAALALPSLCPKYRKFQKAFGTDRVR 240 241 TGESSVKDIHASVQPNERSENECLGGVPECRDLQVMLKCDESKLAMEPEETKKDPASQCP 300 301 TEKSEVTPFPHNSSIDPHGLYSLSLLHTYDQYGDLNFAGMQNTTVLTEKPLSGTDVQEKT 360 361 FGESQDLPLKSDLGTREDSSVASSDRSSVEREVAEHLAKGFWSDICSTDTPCQMQLSPAV 420 421 AKDGSEQISQKRSECPWLGIRISESPEPGQRTFTTLSSVNCPFISTLSTEGCSSNLEIGN 480 481 DDYVSEPQQEPCPYACVISLGDDSETDTEGDSESCSAREQECEVKLPFNAQRIISLSRND 540 541 FQSLLKMHKLTPEQLDCIHDIRRRSKNRIAAQRCRKRKLDCIQNLESEIEKLQSEKESLL 600 601 KERDHILSTLGETKQNLTGLCQKVCKEAALSQEQIQILAKYSAADCPLSFLISEKDKSTP 660 661 DGELALPSIFSLSDRPPAVLPPCARGNSEPGYARGQESQQMSTATSEQAGPAEQCRQSGG 720 721 ISDFCQQMTDKCTTDE |
| Interface Residues: | 563, 567, 568, 570, 571, 574, 575, 578 |
| 3D-footprint Homologues: | 1skn_P, 2wt7_A, 7x5e_F, 2wt7_B, 5t01_B, 5vpe_D |
| Binding Motifs: | MA1633.2 ATGACTCAt BACH1_HUMAN.H10MO.A|M01024 tGCTGAGTCAbss MA1633.1 saTGACTCAGCaw |
| Binding Sites: | MA1633.1.1 MA1633.1.10 / MA1633.1.8 MA1633.1.11 MA1633.1.12 MA1633.1.13 MA1633.1.14 MA1633.1.15 MA1633.1.16 MA1633.1.17 MA1633.1.18 MA1633.1.19 MA1633.1.2 MA1633.1.20 MA1633.1.3 MA1633.1.4 MA1633.1.5 MA1633.1.6 MA1633.1.7 MA1633.1.9 |
| Publications: | Oyake T., Itoh K., Motohashi H., Hayashi N., Hoshino H., Nishizawa M., Yamamoto M., Igarashi K. Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. Mol. Cell. Biol. 16:6083-6095 (1996). [Pubmed] |
| Related annotations: | PaperBLAST |
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