Transcription Factor

Accessions: O22176 (JASPAR 2024), T09826 (AthalianaCistrome v4_May2016)
Names: Probable WRKY transcription factor 15, WRK15_ARATH, WRKY DNA-binding protein 15, AT2G23320, T09826;, WRKY15
Organisms: Arabidopsis thaliana
Libraries: JASPAR 2024 1, AthalianaCistrome v4_May2016 2
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
2 O'Malley RC, Huang SS, Song L, Lewsey MG, Bartlett A, Nery JR, Galli M, Gallavotti A, Ecker JR. Cistrome and Epicistrome Features Shape the Regulatory DNA Landscape. Cell 165:1280-92 (2016). [Pubmed]
Uniprot: O22176
Notes: ecotype:Col-0, experiment type: ampDAP-seq, experiment type: ampDAP-seq (methyl-cytosines removed by PCR), experiment type: DAP-seq, family:WRKY
Length: 317
Pfam Domains: 190-237 Plant zinc cluster domain
241-298 WRKY DNA -binding domain
Sequence:
(in bold interface residues)
1 MAVELMTRNYISGVGADSFAVQEAAASGLKSIENFIGLMSRDSFNSDQPSSSSASASASA 60
61 AADLESARNTTADAAVSKFKRVISLLDRTRTGHARFRRAPVHVISPVLLQEEPKTTPFQS 120
121 PLPPPPQMIRKGSFSSSMKTIDFSSLSSVTTESDNQKKIHHHQRPSETAPFASQTQSLST 180
181 TVSSFSKSTKRKCNSENLLTGKCASASSSGRCHCSKKRKIKQRRIIRVPAISAKMSDVPP 240
241 DDYSWRKYGQKPIKGSPHPRGYYKCSSVRGCPARKHVERAADDSSMLIVTYEGDHNHSLS 300
301 AADLAGAAVADLILESS
Interface Residues: 246, 247, 248, 250, 251, 262
3D-footprint Homologues: 6j4e_B, 6j4f_F, 6j4g_B, 6ir8_A, 7z0u_A
Binding Motifs: MA1076.1 arGTCAAmgs
M0791 aaAAGTCAACg
M0813 kcGTTGACTTTt
MA1076.2 wwwwwrGTCAACGdtw
MA1076.3 rGTCAACG
Binding Sites: MA1076.3.10 / MA1076.3.11 / MA1076.3.13 / MA1076.3.2 / MA1076.3.4 / MA1076.3.5 / MA1076.3.8 / MA1076.3.9
MA1076.3.15 / MA1076.3.6
MA1076.3.20
MA1076.1.1
MA1076.1.10
MA1076.1.11
MA1076.1.12
MA1076.1.13
MA1076.1.14
MA1076.1.15
MA1076.1.16
MA1076.1.17
MA1076.1.18
MA1076.1.19
MA1076.1.2
MA1076.1.20
MA1076.1.3
MA1076.1.4
MA1076.1.5
MA1076.1.6
MA1076.1.7
MA1076.1.8
MA1076.1.9
MA1076.2.1
MA1076.2.10
MA1076.2.11
MA1076.2.12
MA1076.2.13 / MA1076.2.7
MA1076.2.14 / MA1076.2.8
MA1076.2.15 / MA1076.2.9
MA1076.2.16
MA1076.2.17
MA1076.2.18
MA1076.2.10 / MA1076.2.19
MA1076.2.2
MA1076.2.20
MA1076.2.2 / MA1076.2.3
MA1076.2.4
MA1076.2.5
MA1076.2.3 / MA1076.2.6
MA1076.2.4 / MA1076.2.7
MA1076.2.5 / MA1076.2.8
MA1076.2.6 / MA1076.2.9
MA1076.2.11
MA1076.2.12
MA1076.2.13
MA1076.2.14
MA1076.2.15
MA1076.2.16
MA1076.2.17
MA1076.2.18
MA1076.2.19
MA1076.2.20
MA1076.3.1 / MA1076.3.12 / MA1076.3.14 / MA1076.3.17
MA1076.3.16
MA1076.3.18
MA1076.3.19
MA1076.3.3
MA1076.3.7
Publications: Yu D, Chen C, Chen Z. 2001. Evidence for an important role of WRKY DNA binding proteins in the regulation of NPR1 gene expression. Plant Cell. 13:1527-40. [Pubmed]

Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
Related annotations: PaperBLAST

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