Transcription Factor
| Accessions: | RUNX2_HUMAN (HOCOMOCO 10), Q13950 (JASPAR 2024) |
| Names: | Acute myeloid leukemia 3 protein, CBF-alpha-1, Core-binding factor subunit alpha-1, Oncogene AML-3, OSF-2, Osteoblast-specific transcription factor 2, PEA2-alpha A, PEBP2-alpha A, Polyomavirus enhancer-binding protein 2 alpha A subunit, Runt-related transcription factor 2, RUNX2_HUMAN, SL3-3 enhancer factor 1 alpha A subunit, SL3/AKV core-binding factor alpha A subunit |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 521 |
| Pfam Domains: | 100-233 Runt domain 427-521 Runx inhibition domain |
| Sequence: (in bold interface residues) | 1 MASNSLFSTVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQ 60 61 QQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAELVRTDSPN 120 121 FLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVA 180 181 RFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRRHRQKLDDSKPS 240 241 LFSDRLSDLGRIPHPSMRVGVPPQNPRPSLNSAPSPFNPQGQSQITDPRQAQSSPPWSYD 300 301 QSYPSYLSQMTSPSIHSTTPLSSTRGTGLPAITDVPRRISDDDTATSDFCLWPSTLSKKS 360 361 QAGASELGPFSDPRQFPSISSLTESRFSNPRMHYPATFTYTPPVTSGMSLGMSATTHYHT 420 421 YLPPPYPGSSQSQSGPFQTSSTPYLYYGTSSGSYQFPMVPGGDRSPSRMLPPCTTTSNGS 480 481 TLLNPNLPNQNDGVDADGSHSSSPTVLNSSGRMDESVWRPY |
| Interface Residues: | 131, 193, 221, 222, 225, 228 |
| 3D-footprint Homologues: | 6vgd_D, 4l0y_A, 4l18_E, 6vg8_D, 3wts_A |
| Binding Motifs: | MA0511.2 wAACCRCAa MA0511.1 kkkktyTGTGGTttk RUNX2_HUMAN.H10MO.B|M01491 yTGTGGTtdgk |
| Binding Sites: | MA0511.1.1 MA0511.1.10 MA0511.1.11 MA0511.1.12 MA0511.1.13 MA0511.1.14 MA0511.1.15 MA0511.1.16 MA0511.1.17 MA0511.1.18 MA0511.1.19 MA0511.1.2 MA0511.1.20 MA0511.1.3 MA0511.1.4 MA0511.1.5 MA0511.1.6 MA0511.1.7 MA0511.1.8 MA0511.1.9 |
| Publications: | Bowers S. R., Calero-Nieto F. J., Valeaux S., Fernandez-Fuentes N., Cockerill P. N. Runx1 binds as a dimeric complex to overlapping Runx1 sites within a palindromic element in the human GM-CSF enhancer.. Nucleic Acids Res. 38:6124-6134 (2010). [Pubmed] van der Deen M, Akech J, Lapointe D, Gupta S, Young D.W, Montecino M.A, Galindo M, Lian J.B, Stein J.L, Stein G.S, van Wijnen A.J. Genomic promoter occupancy of runt-related transcription factor RUNX2 in Osteosarcoma cells identifies genes involved in cell adhesion and motility. The Journal of biological chemistry 287:4503-17 (2012). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.