Transcription Factor
| Accessions: | GABPA_HUMAN (HOCOMOCO 10), Q06546 (JASPAR 2024) |
| Names: | GA-binding protein alpha chain, GABP subunit alpha, GABPA_HUMAN, Nuclear respiratory factor 2 subunit alpha, Transcription factor E4TF1-60 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 454 |
| Pfam Domains: | 35-122 GA-binding protein alpha chain 171-250 Sterile alpha motif (SAM)/Pointed domain 319-401 Ets-domain |
| Sequence: (in bold interface residues) | 1 MTKREAEELIEIEIDGTEKAECTEESIVEQTYAPAECVSQAIDINEPIGNLKKLLEPRLQ 60 61 CSLDAHEICLQDIQLDPERSLFDQGVKTDGTVQLSVQVISYQGIEPKLNILEIVKPADTV 120 121 EVVIDPDAHHAESEAHLVEEAQVITLDGTKHITTISDETSEQVTRWAAALEGYRKEQERL 180 181 GIPYDPIQWSTDQVLHWVVWVMKEFSMTDIDLTTLNISGRELCSLNQEDFFQRVPRGEIL 240 241 WSHLELLRKYVLASQEQQMNEIVTIDQPVQIIPASVQSATPTTIKVINSSAKAAKVQRAP 300 301 RISGEDRSSPGNRTGNNGQIQLWQFLLELLTDKDARDCISWVGDEGEFKLNQPELVAQKW 360 361 GQRKNKPTMNYEKLSRALRYYYDGDMICKVQGKRFVYKFVCDLKTLIGYSAAELNRLVTE 420 421 CEQKKLAKMQLHGIAQPVTAVALATASLQTEKDN |
| Interface Residues: | 317, 372, 373, 375, 376, 377, 379, 380, 394 |
| 3D-footprint Homologues: | 3zp5_A, 1dux_F, 7jsa_J, 8ee9_F, 4mhg_A, 2stt_A, 4uno_A, 3jtg_A, 4l18_B, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C |
| Binding Motifs: | MA0062.1 ACCGGAAGws GABPA_HUMAN.H10MO.A|M01171 svrCCGGAAGTgr MA0062.3 yycACTTCCTGtyy MA0062.4 cACTTCCTGt |
| Binding Sites: | MA0062.1.1 MA0062.1.2 / MA0062.1.3 MA0062.1.7 MA0062.1.6 MA0062.1.5 MA0062.1.4 MA0062.3.1 MA0062.3.10 / MA0062.3.6 MA0062.3.11 / MA0062.3.7 MA0062.3.12 MA0062.3.13 / MA0062.3.8 MA0062.3.14 / MA0062.3.9 MA0062.3.10 / MA0062.3.15 MA0062.3.11 / MA0062.3.16 MA0062.3.12 / MA0062.3.17 MA0062.3.18 MA0062.3.19 MA0062.3.2 MA0062.3.20 MA0062.3.3 MA0062.3.4 MA0062.3.5 MA0062.3.6 MA0062.3.4 / MA0062.3.7 MA0062.3.5 / MA0062.3.8 MA0062.3.9 MA0062.3.1 MA0062.3.13 MA0062.3.14 MA0062.3.15 MA0062.3.16 MA0062.3.17 MA0062.3.18 MA0062.3.19 MA0062.3.20 MA0062.4.1 MA0062.4.10 MA0062.4.11 / MA0062.4.4 MA0062.4.12 MA0062.4.13 MA0062.4.14 MA0062.4.15 MA0062.4.16 MA0062.4.17 MA0062.4.18 MA0062.4.19 MA0062.4.2 MA0062.4.20 MA0062.4.3 / MA0062.4.7 MA0062.4.5 MA0062.4.6 MA0062.4.8 MA0062.4.9 |
| Publications: | Virbasius J. V., Virbasius C.-M. A., Scarpulla R. C. Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an Ets domain activator of viral promoters. Genes Dev. 7:380-392 (1993). [Pubmed] Batchelor A.H, Piper D.E, de la Brousse F.C, McKnight S.L, Wolberger C. The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA. Science (New York, N.Y.) 279:1037-41 (1998). [Pubmed] |
| Related annotations: | PaperBLAST |
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