Transcription Factor
| Accessions: | CUX1_DBD (HumanTF 1.0), CUX1_TF1 (HumanTF2 1.0), CUX1 (HT-SELEX2 May2017) |
| Names: | CCAAT displacement protein, CDP, CUX1, CUX1_HUMAN, Homeobox protein cut-like 1, Homeobox protein cux-1, ENSG00000257923 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2, HT-SELEX2 May2017 3 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 3 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | P39880 |
| Notes: | Ensembl ID: ENSG00000160967; DNA-binding domain sequence; TF family: homeodomain+cut; Clone source: Gene synthesis, Ensembl ID: ENSG00000160967; Construct type: TF1(SBP); TF family: Homeodomain+Cut; Clone source: Jolma et al. 2013, TF family: CUT_Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: CUT_Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 826 |
| Pfam Domains: | 38-115 CUT domain 428-502 CUT domain 613-691 CUT domain 737-793 Homeobox domain 757-790 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 TGPYSTNSISSQSPLQQSPDVNGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLIKHN 60 61 IGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQG 120 121 RQRENPGQSLNRLFQEVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTA 180 181 EPAQPSSASGSGNSDDAIRSILQQARREMEAQQAALDPALKQAPLSQSDITILTPKLLST 240 241 SPMPTVSSYPPLAISLKKPSAAPEAGASALPNPPALKKEAQDAPGLDPQGAADCAQGVLR 300 301 QVKNEVGRSGAWKDHWWSAVQPERRNAASSEEAKAEETGGGKEKGSGGSGGGSQPRAERS 360 361 QLQGPSSSEYWKEWPSAESPYSQSSELSLTGASRSETPQNSPLPSSPIVPMSKPTKPSVP 420 421 PLTPEQYEVYMYQEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPW 480 481 SKLTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSESTPK 540 541 TSASCSPAPESPMSSSESVKSLTELVQQPCPPIEASKDSKPPEPSDPPASDSQPTTPLPL 600 601 SGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARP 660 661 KPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSV 720 721 GTEYSQGASPQPQHQLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEDLATQLNLKTSTV 780 781 INWFHNYRSRIRRELFIEEIQAGSQGQAGASDSPSARSGRAAPSSE |
| Interface Residues: | 74, 75, 77, 79, 80, 649, 650, 652, 654, 655, 737, 738, 740, 781, 782, 785, 786, 789, 790, 793 |
| 3D-footprint Homologues: | 2o4a_A, 2d5v_B, 6a8r_A, 3cmy_A, 1fjl_B, 5zfz_A, 3d1n_M, 1ig7_A, 6m3d_C, 1zq3_P, 1nk2_P, 2lkx_A, 3l1p_A, 2hdd_A, 4xrs_G, 3lnq_A, 2hos_A, 5hod_A, 1au7_A, 7xrc_C, 2xsd_C, 1e3o_C, 4xrm_B, 1puf_B, 1du0_A, 1jgg_B, 6fqp_B, 8g87_X, 6fqq_E, 4qtr_D, 1o4x_A, 2h1k_B |
| Binding Motifs: | CUX1_DBD_1 ATCrATmmstrATCrAT CUX1_DBD_2 ATCRATmmsstrATCrAT CUX1_DBD_3 TrATCrATam CUX1_FOXI1 rTmawCAcgmkrATCRATt CUX1_FOXO1 rtAAayAaaatgATCrATa CUX1_FOXO6 rtmaaCaaahtrATCrATa CUX1_HOXA13_1 ATCGATyAysycrTmAA CUX1_HOXA13_2 cyCrTAAAwATyGATc CUX1_HOXB13 symrTAAAhATyGATy CUX1_NHLH1_1 cGCAGCTGCkcmmamwATyGATy CUX1_NHLH1_2 mgCAGCTGCkcymmytyATyGATc CUX1_PITX1 gGATTAwstkATCrATr CUX1_RFX5_1 rATCrATagsmdtrCwTaGyAAC CUX1_RFX5_2 rATCRATracktsCcTAGyAAC CUX1_SOX15_1 ATCrATwsayatrssywTTGtt CUX1_SOX15_2 dATCrATrammdkbrwCAAwrs CUX1_SOX15_2_3 rATCrATammcktwrawCAAwrs CUX1_SRF rCCwTAyAwGGtmrkrATCrATw CUX1_TBX21_1 kTcACACmyyrATCrATm CUX1_TBX21_2 tCACACCyrATa CUX1_TBX3 rgGTGTgrrtGATCrAT CUX1_2 ktATyGATyr CUX1_methyl_1 ktATTGATyr |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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