Transcription Factor

						

			
Accessions: P20265 (JASPAR 2024)

			
Names: Brain-2, Brain-specific homeobox/POU domain protein 2, Brn-2, Nervous system-specific octamer-binding transcription factor N-Oct-3, Oct-7, Octamer-binding protein 7, Octamer-binding transcription factor 7, OTF-7, PO3F2_HUMAN, POU domain, class 3, transcription factor 2
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P20265
Length: 443
Pfam Domains:   263-336 Pou domain - N-terminal to homeobox domain
  355-411 Homeobox domain
Sequence: 
(in bold interface residues)		   1 MATAASNHYSLLTSSASIVHAEPPGGMQQGAGGYREAQSLVQGDYGALQSNGHPLSHAHQ   60
  61 WITALSHGGGGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQPDIKPSVVVQQGGRGDELHG  120
 121 PGALQQQHQQQQQQQQQQQQQQQQQQQQQRPPHLVHHAANHHPGPGAWRSAAAAAHLPPS  180
 181 MGASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQQPP  240
 241 PPPPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYG  300
 301 NVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTS  360
 361 IEVSVKGALESHFLKCPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLP  420
 421 GAEDVYGGSRDTPPHHGVQTPVQ
Interface Residues: 288, 304, 305, 306, 307, 309, 310, 316, 320, 353, 355, 356, 357, 358, 396, 397, 399, 400, 403, 404, 407, 408, 411
3D-footprint Homologues: 3d1n_M, 7u0g_M, 3l1p_A, 1o4x_A, 8g87_X, 2xsd_C, 1e3o_C, 7xrc_C, 1au7_A, 3lnq_A, 1fjl_B, 3cmy_A, 2h1k_B, 5zjt_E, 1puf_A, 1ig7_A, 6a8r_A, 5zfz_A, 2lkx_A, 1jgg_B, 1nk2_P, 1zq3_P, 2ld5_A, 1b72_A, 3rkq_B, 2r5y_A, 5hod_A, 1puf_B, 4xrs_G, 3a01_E, 5jlw_D, 1le8_A, 7q3o_C, 7psx_B, 5flv_I, 2hdd_A, 1mnm_C, 1du0_A, 4cyc_A, 6es3_K, 1k61_B
Binding Motifs: MA0787.1 wTATGCwAATka
			
Publications: Rhee J. M., Gruber C. A., Brodie T. B., Trieu M., Turner E. E. Highly cooperative homodimerization is a conserved property of neural POU proteins. J. Biol. Chem. 273:34196-34205 (1998). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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