Transcription Factor
| Accessions: | NR2C2_HUMAN (HOCOMOCO 10), P49116 (JASPAR 2024) |
| Names: | NR2C2_HUMAN, Nuclear receptor subfamily 2 group C member 2, Orphan nuclear receptor TAK1, Orphan nuclear receptor TR4, Testicular receptor 4 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 596 |
| Pfam Domains: | 116-183 Zinc finger, C4 type (two domains) 371-567 Ligand-binding domain of nuclear hormone receptor |
| Sequence: (in bold interface residues) | 1 MTSPSPRIQIISTDSAVASPQRIQIVTDQQTGQKIQIVTAVDASGSPKQQFILTSPDGAG 60 61 TGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKTDVQRPQVVEYCVVC 120 121 GDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKKCLEM 180 181 GMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLL 240 241 DPGMLVNIQQPLIREDGTVLLATDSKAETSQGALGTLANVVTSLANLSESLNNGDTSEIQ 300 301 PEDQSASEITRAFDTLAKALNTTDSSSSPSLADGIDTSGGGSIHVISRDQSTPIIEVEGP 360 361 LLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVR 420 421 ACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCN 480 481 SMAKLDIDGYEYAYLKAIVLFSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRL 540 541 ARILVRLPALRLMSSNITEELFFTGLIGNVSIDSIIPYILKMETAEYNGQITGASL |
| Interface Residues: | 125, 126, 128, 129, 135, 136, 138, 139, 142, 143, 167, 189, 191, 193 |
| 3D-footprint Homologues: | 6fbq_A, 6l6q_B, 7wnh_D, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A |
| Binding Motifs: | MA0504.1 mgrGGTCArAGGTCA MA1536.1 rrGGTCRh NR2C2_HUMAN.H10MO.A|M01392 rGGtcArAGGtCA MA0504.2 grGGTCArAGGTCA MA1536.2 rGGTCR |
| Binding Sites: | MA0504.1.1 MA0504.1.10 MA0504.1.11 MA0504.1.12 MA0504.1.13 MA0504.1.14 MA0504.1.15 MA0504.1.16 MA0504.1.17 MA0504.1.18 MA0504.1.19 MA0504.1.2 MA0504.1.20 MA0504.1.3 MA0504.1.4 MA0504.1.5 MA0504.1.6 MA0504.1.7 MA0504.1.8 MA0504.1.9 MA0504.2.1 MA0504.2.10 MA0504.2.11 MA0504.2.12 MA0504.2.13 MA0504.2.14 MA0504.2.15 MA0504.2.16 MA0504.2.17 MA0504.2.18 MA0504.2.19 MA0504.2.2 MA0504.2.20 MA0504.2.3 MA0504.2.4 MA0504.2.5 MA0504.2.6 MA0504.2.7 MA0504.2.8 MA0504.2.9 |
| Publications: | Lee H.J, Lee Y.F, Chang C. TR4 orphan receptor represses the human steroid 21-hydroxylase gene expression through the monomeric AGGTCA motif. Biochemical and biophysical research communications 285:1361-8 (2001). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.