Transcription Factor

Accessions: Q02556 (JASPAR 2024)
Names: H-ICSBP, Interferon consensus sequence-binding protein, Interferon regulatory factor 8, IRF-8, IRF8_HUMAN
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q02556
Length: 426
Pfam Domains: 9-114 Interferon regulatory factor transcription factor
203-381 Interferon-regulatory factor 3
Sequence:
(in bold interface residues)
1 MCDRNGGRRLRQWLIEQIDSSMYPGLIWENEEKSMFRIPWKHAGKQDYNQEVDASIFKAW 60
61 AVFKGKFKEGDKAEPATWKTRLRCALNKSPDFEEVTDRSQLDISEPYKVYRIVPEEEQKC 120
121 KLGVATAGCVNEVTEMECGRSEIDELIKEPSVDDYMGMIKRSPSPPEACRSQLLPDWWAQ 180
181 QPSTGVPLVTGYTTYDAHHSAFSQMVISFYYGGKLVGQATTTCPEGCRLSLSQPGLPGTK 240
241 LYGPEGLELVRFPPADAIPSERQRQVTRKLFGHLERGVLLHSSRQGVFVKRLCQGRVFCS 300
301 GNAVVCKGRPNKLERDEVVQVFDTSQFFRELQQFYNSQGRLPDGRVVLCFGEEFPDMAPL 360
361 RSKLILVQIEQLYVRQLAEEAGKSCGAGSVMQAPEEPPPDQVFRMFPDICASHQRSFFRE 420
421 NQQITV
Interface Residues: 42, 44, 76, 80, 81, 83, 84, 87, 88
3D-footprint Homologues: 2pi0_B, 1if1_B, 2o61_A, 2irf_L, 7oot_B
Binding Motifs: MA0652.1 yCGAAACCGAAACT
MA0652.2 CGAAACCGAAACT
Publications: Marquis JF, Kapoustina O, Langlais D, Ruddy R, Dufour CR, Kim BH, MacMicking JD, Giguère V, Gros P. Interferon regulatory factor 8 regulates pathways for antigen presentation in myeloid cells and during tuberculosis. PLoS Genet : (2011). [Pubmed]
Related annotations: PaperBLAST

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