Transcription Factor

Accessions: ELK1_HUMAN (HOCOMOCO 10), P19419 (JASPAR 2024)
Names: ELK1_HUMAN
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P19419
Length: 428
Pfam Domains: 5-87 Ets-domain
Sequence:
(in bold interface residues)
1 MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKL 60
61 SRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSTMPNVAPAAIH 120
121 AAPGDTVSGKPGTPKGAGMAGPGGLARSSRNEYMRSGLYSTFTIQSLQPQPPPHPRPAVV 180
181 LPSAAPAGAAAPPSGSRSTSPSPLEACLEAEEAGLPLQVILTPPEAPNLKSEELNVEPGL 240
241 GRALPPEVKVEGPKEELEVAGERGFVPETTKAEPEVPPQEGVPARLPAVVMDTAGQAGGH 300
301 AASSPEISQPQKGRKPRDLELPLSPSLLGGPGPERTPGSGSGSGLQAPGPALTPSLLPTH 360
361 TLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVV 420
421 LSPGPQKP
Interface Residues: 58, 59, 61, 62, 63, 65, 66, 80
3D-footprint Homologues: 3jtg_A, 1dux_F, 7jsa_J, 3zp5_A, 8ee9_F, 4mhg_A, 2stt_A, 4uno_A, 4l18_B, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C
Binding Motifs: UN0494.1 rcCGGAAGTrgGyGygA
UN0498.1 rcCGGwAAtkr-
UN0499.1 rCCGGAAscGATCGATam
UN0500.1 aCCGGAACyACGCwTsRsYg
UN0503.1 mcmGGAmGGAwATCCKgg
UN0552.1 rTryGGGCGGAAGTr
MA1957.1 rcCGGAAGTmrTTA
UN0560.1 TAATkrCCGGAAGTr
UN0578.1 mCCGsATATGCAm
ELK1_HUMAN.H10MO.A|M01106 rCCGGAArt
MA0028.1 varcCGGAAr
MA0028.2 ACCGGAAGTr
MA0028.3 ACCGGAAGT
UN0498.2 cCGGwAAtkr
UN0499.2 rCCGGAAscGATCGAT
UN0503.2 cmGGAmGGAwATCCKg
UN0552.2 TryGGGCGGAAGT
UN0560.2 TAATkrCCGGAAGT
Binding Sites: MA0028.1.1
MA0028.1.10
MA0028.1.11
MA0028.1.12
MA0028.1.13
MA0028.1.14
MA0028.1.15
MA0028.1.16
MA0028.1.17
MA0028.1.18
MA0028.1.19
MA0028.1.2
MA0028.1.20
MA0028.1.3
MA0028.1.4
MA0028.1.5
MA0028.1.6
MA0028.1.7
MA0028.1.8
MA0028.1.9
Publications: Treisman R., Marais R., Wynne J. Spatial flexibility in ternary complexes between SRF and its accessory proteins. EMBO J. 11:4631-4640 (1992). [Pubmed]

Guturu H, Doxey AC, Wenger AM, Bejerano G. Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements. Philos Trans R Soc Lond B Biol Sci 368:20130029 (2013). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.