Transcription Factor

						

			
Accessions: O14813 (JASPAR 2024)

			
Names: Aristaless homeobox protein homolog, ARIX1 homeodomain protein, Paired mesoderm homeobox protein 2A, Paired-like homeobox 2A, PHX2A_HUMAN
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: O14813
Length: 284
Pfam Domains:    91-147 Homeobox domain
Sequence: 
(in bold interface residues)		   1 MDYSYLNSYDSCVAAMEASAYGDFGACSQPGGFQYSPLRPAFPAAGPPCPALGSSNCALG   60
  61 ALRDHQPAPYSAVPYKFFPEPSGLHEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTR  120
 121 EELALKIDLTEARVQVWFQNRRAKFRKQERAASAKGAAGAAGAKKGEARCSSEDDDSKES  180
 181 TCSPTPDSTASLPPPPAPGLASPRLSPSPLPVALGSGPGPGPGPQPLKGALWAGVAGGGG  240
 241 GGPGAGAAELLKAWQPAESGPGPFSGVLSSFHRKPGPALKTNLF
Interface Residues: 85, 90, 91, 92, 93, 94, 132, 133, 135, 136, 139, 140, 143, 144, 146, 147, 150
3D-footprint Homologues: 3a01_E, 1nk2_P, 4j19_B, 3d1n_M, 5zfz_A, 1fjl_B, 1ig7_A, 6a8r_A, 3cmy_A, 2h1k_B, 1puf_A, 1zq3_P, 3lnq_A, 1jgg_B, 2lkx_A, 2ld5_A, 7q3o_C, 6es3_K, 2hdd_A, 1au7_A, 4cyc_A, 2r5y_A, 1puf_B, 6m3d_C, 5flv_I, 3l1p_A, 2hos_A, 1b72_A, 5zjt_E, 7psx_B, 5hod_A, 5jlw_D, 3rkq_B, 4xrs_G, 1le8_A, 1e3o_C, 8g87_X, 1o4x_A, 1du0_A, 4qtr_D
Binding Motifs: MA0713.1 TAAtyyAATTA
			
Publications: Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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