Transcription Factor
| Accessions: | AP2A_HUMAN (HOCOMOCO 10), P05549 (JASPAR 2024) |
| Names: | Activating enhancer-binding protein 2-alpha, Activator protein 2, AP-2 transcription factor, AP2-alpha, AP2A_HUMAN, Transcription factor AP-2-alpha |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 437 |
| Pfam Domains: | 207-413 Transcription factor AP-2 |
| Sequence: (in bold interface residues) | 1 MLWKLTDNIKYEDCEDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPP 60 61 PYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSG 120 121 LDPRRDYRRHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDPGINIPDQTVIKKGPV 180 181 SLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSP 240 241 PECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHL 300 301 ARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLG 360 361 NSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNS 420 421 HTDNNAKSSDKEEKHRK |
| Interface Residues: | 222, 256, 257 |
| 3D-footprint Homologues: | 8j0k_B |
| Binding Motifs: | MA0003.1 GCCcbrrGs MA0810.1 ysCCCyvrGGCa MA0003.3 hGCCysAGGCw MA0003.2 maywGCCysAGGsCa AP2A_HUMAN.H10MO.C|M01007 atksCCTGrGGsmat MA0872.1 tGCCCysrGGGCa MA0003.4 vytgCCTCAGGsma MA0003.5 gCCTCAGGs MA0810.2 ysCCCyvrGGC |
| Binding Sites: | MA0003.5.1 / MA0003.5.11 MA0003.2.1 MA0003.2.10 MA0003.2.11 MA0003.2.12 MA0003.2.13 MA0003.2.14 MA0003.2.15 MA0003.2.16 MA0003.2.17 MA0003.2.18 MA0003.2.19 MA0003.2.2 MA0003.2.20 MA0003.2.3 MA0003.2.4 MA0003.2.5 MA0003.2.6 MA0003.2.7 MA0003.2.8 MA0003.2.9 MA0003.4.1 MA0003.4.10 MA0003.4.11 / MA0003.4.9 MA0003.4.12 MA0003.4.13 MA0003.4.11 / MA0003.4.14 MA0003.4.15 MA0003.4.12 / MA0003.4.16 MA0003.4.17 MA0003.4.18 MA0003.4.13 / MA0003.4.19 MA0003.4.1 / MA0003.4.2 MA0003.4.20 MA0003.4.2 / MA0003.4.3 MA0003.4.4 MA0003.4.5 MA0003.4.6 MA0003.4.6 / MA0003.4.7 MA0003.4.7 / MA0003.4.8 MA0003.4.8 / MA0003.4.9 MA0003.4.10 MA0003.4.14 MA0003.4.15 MA0003.4.16 MA0003.4.17 MA0003.4.18 MA0003.4.19 MA0003.4.20 MA0003.4.3 MA0003.5.10 MA0003.5.12 / MA0003.5.18 / MA0003.5.4 MA0003.5.13 MA0003.5.14 / MA0003.5.15 MA0003.5.16 / MA0003.5.9 MA0003.5.17 MA0003.5.19 MA0003.5.2 MA0003.5.20 MA0003.5.3 MA0003.5.5 MA0003.5.6 MA0003.5.7 MA0003.5.8 |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Eckert D, Buhl S, Weber S, Jäger R, Schorle H. The AP-2 family of transcription factors. Genome Biol : (2005;6(13):246.). [Pubmed] |
| Related annotations: | PaperBLAST |
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