Transcription Factor
| Accessions: | CREB3 (HT-SELEX2 May2017), O43889 (JASPAR 2024) |
| Names: | CREB3, ENSG00000107175, cAMP-responsive element-binding protein 3, CREB-3, CREB3_HUMAN, Cyclic AMP-responsive element-binding protein 3, Leucine zipper protein, Luman, N-terminal Luman, Transcription factor LZIP-alpha, Transcriptionally active form |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1, JASPAR 2024 2 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | TF family: bZIP experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: bZIP experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 371 |
| Pfam Domains: | 150-209 bZIP transcription factor 152-201 Basic region leucine zipper |
| Sequence: (in bold interface residues) | 1 MELELDAGDQDLLAFLLEESGDLGTAPDEAVRAPLDWALPLSEVPSDWEVDDLLCSLLSP 60 61 PASLNILSSSNPCLVHHDHTYSLPRETVSMDLESESCRKEGTQMTPQHMEELAEQEIARL 120 121 VLTDEEKSLLEKEGLILPETLPLTKTEEQILKRVRRKIRNKRSAQESRRKKKVYVGGLES 180 181 RVLKYTAQNMELQNKVQLLEEQNLSLLDQLRKLQAMVIEISNKTSSSSTCILVLLVSFCL 240 241 LLVPAMYSSDTRGSLPAEHGVLSRQLRALPSEDPYQLELPALQSEVPKDSTHQWLDGSDC 300 301 VLQAPGNTSCLLHYMPQAPSAEPPLEWPFPDLFSEPLCRGPILPLQANLTRKGGWLPTGS 360 361 PSVILQDRYSG |
| Interface Residues: | 157, 160, 161, 163, 164, 167, 168 |
| 3D-footprint Homologues: | 6mg1_B, 5t01_B, 5vpe_D, 1dh3_C |
| Binding Motifs: | MA0638.1 rtGmCACGTCAycr CREB3_4 ykmCACGTCAyc CREB3_5 grTGACGTCAyc CREB3_6 ygCCACGTgkmm CREB3_methyl_1 ykCCACrTCAyc CREB3_methyl_2 grTGAyGTCAyc CREB3_methyl_3 yGCcACGTgkmm MA0638.2 tGmCACGTCAyc |
| Publications: | DenBoer LM, Hardy-Smith PW, Hogan MR, Cockram GP, Audas TE, Lu R. Luman is capable of binding and activating transcription from the unfolded protein response element. Biochem Biophys Res Commun 331:113-9 (2005). [Pubmed] |
| Related annotations: | PaperBLAST |
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