Transcription Factor
| Accessions: | O35652 (JASPAR 2024) |
| Names: | L3, LHX8_MOUSE, LIM homeobox protein 7, LIM homeobox protein 8, LIM/homeobox protein Lhx7, LIM/homeobox protein Lhx8 |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 367 |
| Pfam Domains: | 96-152 LIM domain 157-211 LIM domain 247-303 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MYWKSDQMFVCKLEGKEVPELAVPREKCPGLMSEECGRPAALAAGRTRKGAGEEGLVNPE 60 61 GAGDEDSCSSSAPLSPSSSPQSMASGSVCPPGKCVCSSCGLEIVDKYLLKVNDLCWHVRC 120 121 LSCSVCRTSLGRHTSCYIKDKDIFCKLDYFRRYGTRCSRCGRHIHSTDWVRRAKGNVYHL 180 181 ACFACFSCKRQLSTGEEFALVEEKVLCRVHFDCMLDNLKREVENGNGISVEGALLTEQDV 240 241 NHPKPAKRARTSFTADQLQVMQAQFAQDNNPDAQTLQKLAERTGLSRRVIQVWFQNCRAR 300 301 HKKHVSPNHSSSAPVTAVPSSRLSPPMLEEMAYSAYVPQDGTMLTALHSYMDAHQQLLDS 360 361 SPCYPIQ |
| Interface Residues: | 247, 248, 249, 250, 288, 289, 291, 292, 295, 296, 299, 300, 303 |
| 3D-footprint Homologues: | 2h1k_B, 1ig7_A, 1puf_A, 6a8r_A, 3cmy_A, 3d1n_M, 5zfz_A, 1fjl_B, 1nk2_P, 3lnq_A, 2lkx_A, 1jgg_B, 1zq3_P, 6m3d_C, 2ld5_A, 7q3o_C, 6es3_K, 1b72_A, 5zjt_E, 3a01_E, 7psx_B, 5hod_A, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 4xrs_G, 2hos_A, 1au7_A, 4cyc_A, 5flv_I, 3l1p_A, 1e3o_C, 7xrc_C, 2xsd_C, 4qtr_D, 1du0_A, 4xrm_B, 1le8_B |
| Binding Motifs: | MA0705.1 cYAATYRr PH0098.1 wmmvCTAATTAGCkgtg MA0705.2 YAATYR |
| Publications: | Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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