Transcription Factor
Accessions: | KLF10 (humanC2H2ZF-ChIP Feb2015), Q13118 (JASPAR 2024) |
Names: | ENSG00000155090, KLF10, Q13118, EGR-alpha, KLF10_HUMAN, Krueppel-like factor 10, TGFB-inducible early growth response protein 1, TIEG-1, Transforming growth factor-beta-inducible early growth response protein 1 |
Organisms: | Homo sapiens |
Libraries: | humanC2H2ZF-ChIP Feb2015 1, JASPAR 2024 2 1 Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. C2H2 zinc finger proteins greatly expand the human regulatory lexicon. Nat Biotechnol 33:555-62 (2015). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Notes: | TF family: C2H2 experiment: ChIP-seq/MEME/B1H-RC |
Length: | 480 |
Pfam Domains: | 369-393 C2H2-type zinc finger 385-411 Zinc-finger double domain 399-423 C2H2-type zinc finger 399-423 Zinc finger, C2H2 type 416-438 Zinc-finger double domain 429-451 Zinc finger, C2H2 type 429-451 C2H2-type zinc finger |
Sequence: (in bold interface residues) | 1 MLNFGASLQQTAEERMEMISERPKESMYSWNKTAEKSDFEAVEALMSMSCSWKSDFKKYV 60 61 ENRPVTPVSDLSEEENLLPGTPDFHTIPAFCLTPPYSPSDFEPSQVSNLMAPAPSTVHFK 120 121 SLSDTAKPHIAAPFKEEEKSPVSAPKLPKAQATSVIRHTADAQLCNHQTCPMKAASILNY 180 181 QNNSFRRRTHLNVEAARKNIPCAAVSPNRSKCERNTVADVDEKASAALYDFSVPSSETVI 240 241 CRSQPAPVSPQQKSVLVSPPAVSAGGVPPMPVICQMVPLPANNPVVTTVVPSTPPSQPPA 300 301 VCPPVVFMGTQVPKGAVMFVVPQPVVQSSKPPVVSPNGTRLSPIAPAPGFSPSAAKVTPQ 360 361 IDSSRIRSHICSHPGCGKTYFKSSHLKAHTRTHTGEKPFSCSWKGCERRFARSDELSRHR 420 421 RTHTGEKKFACPMCDRRFMRSDHLTKHARRHLSAKKLPNWQMEVSKLNDIALPPTPAPTQ 480 |
Interface Residues: | 186, 187, 352, 354, 355, 358, 362, 364, 365, 368, 381, 382, 383, 384, 385, 387, 388, 390, 391, 394, 407, 409, 411, 412, 413, 414, 415, 417, 418, 419, 439, 440, 441, 442, 443, 444, 445, 446, 447, 450, 466, 467, 468, 469 |
3D-footprint Homologues: | 1a6y_A, 5ei9_F, 6ml4_A, 3uk3_C, 1tf3_A, 6jnm_A, 8cuc_F, 7y3l_A, 7n5w_A, 1mey_C, 5kl3_A, 7ysf_A, 5k5i_A, 2kmk_A, 2gli_A, 1g2f_F, 1tf6_A, 5v3j_F, 4x9j_A, 2i13_A, 6blw_A, 1ubd_C, 6u9q_A, 8h9h_G, 7eyi_G, 6e94_A, 6wmi_A, 8ssq_A, 7w1m_H, 5und_A, 2lt7_A, 8ssu_A, 5kkq_D, 6a57_A, 2jpa_A, 8gn3_A, 7txc_E, 2drp_D, 1f2i_J, 1llm_D, 2wbs_A, 5yel_A, 4m9v_C, 7y3m_I, 5yj3_D, 5k5l_F |
Binding Motifs: | KLF10_ChIP wGGGyGkGG MA1511.1 gmCACrCCCmy MA1511.2 GGGGCGKGG |
Publications: | Bieker JJ. Krüppel-like factors: three fingers in many pies. J Biol Chem 276:34355-8 (2001). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.