Transcription Factor

Accessions: KLF10 (humanC2H2ZF-ChIP Feb2015), Q13118 (JASPAR 2024)
Names: ENSG00000155090, KLF10, Q13118, EGR-alpha, KLF10_HUMAN, Krueppel-like factor 10, TGFB-inducible early growth response protein 1, TIEG-1, Transforming growth factor-beta-inducible early growth response protein 1
Organisms: Homo sapiens
Libraries: humanC2H2ZF-ChIP Feb2015 1, JASPAR 2024 2
1 Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. C2H2 zinc finger proteins greatly expand the human regulatory lexicon. Nat Biotechnol 33:555-62 (2015). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: TF family: C2H2 experiment: ChIP-seq/MEME/B1H-RC
Length: 480
Pfam Domains: 369-393 C2H2-type zinc finger
385-411 Zinc-finger double domain
399-423 C2H2-type zinc finger
399-423 Zinc finger, C2H2 type
416-438 Zinc-finger double domain
429-451 Zinc finger, C2H2 type
429-451 C2H2-type zinc finger
Sequence:
(in bold interface residues)
1 MLNFGASLQQTAEERMEMISERPKESMYSWNKTAEKSDFEAVEALMSMSCSWKSDFKKYV 60
61 ENRPVTPVSDLSEEENLLPGTPDFHTIPAFCLTPPYSPSDFEPSQVSNLMAPAPSTVHFK 120
121 SLSDTAKPHIAAPFKEEEKSPVSAPKLPKAQATSVIRHTADAQLCNHQTCPMKAASILNY 180
181 QNNSFRRRTHLNVEAARKNIPCAAVSPNRSKCERNTVADVDEKASAALYDFSVPSSETVI 240
241 CRSQPAPVSPQQKSVLVSPPAVSAGGVPPMPVICQMVPLPANNPVVTTVVPSTPPSQPPA 300
301 VCPPVVFMGTQVPKGAVMFVVPQPVVQSSKPPVVSPNGTRLSPIAPAPGFSPSAAKVTPQ 360
361 IDSSRIRSHICSHPGCGKTYFKSSHLKAHTRTHTGEKPFSCSWKGCERRFARSDELSRHR 420
421 RTHTGEKKFACPMCDRRFMRSDHLTKHARRHLSAKKLPNWQMEVSKLNDIALPPTPAPTQ 480
Interface Residues: 186, 187, 352, 354, 355, 358, 362, 364, 365, 368, 381, 382, 383, 384, 385, 387, 388, 390, 391, 394, 407, 409, 411, 412, 413, 414, 415, 417, 418, 419, 439, 440, 441, 442, 443, 444, 445, 446, 447, 450, 466, 467, 468, 469
3D-footprint Homologues: 1a6y_A, 5ei9_F, 6ml4_A, 3uk3_C, 1tf3_A, 6jnm_A, 8cuc_F, 7y3l_A, 7n5w_A, 1mey_C, 5kl3_A, 7ysf_A, 5k5i_A, 2kmk_A, 2gli_A, 1g2f_F, 1tf6_A, 5v3j_F, 4x9j_A, 2i13_A, 6blw_A, 1ubd_C, 6u9q_A, 8h9h_G, 7eyi_G, 6e94_A, 6wmi_A, 8ssq_A, 7w1m_H, 5und_A, 2lt7_A, 8ssu_A, 5kkq_D, 6a57_A, 2jpa_A, 8gn3_A, 7txc_E, 2drp_D, 1f2i_J, 1llm_D, 2wbs_A, 5yel_A, 4m9v_C, 7y3m_I, 5yj3_D, 5k5l_F
Binding Motifs: KLF10_ChIP wGGGyGkGG
MA1511.1 gmCACrCCCmy
MA1511.2 GGGGCGKGG
Publications: Bieker JJ. Krüppel-like factors: three fingers in many pies. J Biol Chem 276:34355-8 (2001). [Pubmed]
Related annotations: PaperBLAST

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