Transcription Factor

Accessions: P35452 (JASPAR 2024)
Names: Homeobox protein Hox-4H, Homeobox protein Hox-D12, HXD12_HUMAN
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P35452
Length: 270
Pfam Domains: 203-259 Homeobox domain
Sequence:
(in bold interface residues)
1 MCERSLYRAGYVGSLLNLQSPDSFYFSNLRPNGGQLAALPPISYPRGALPWAATPASCAP 60
61 AQPAGATAFGGFSQPYLAGSGPLGLQPPTAKDGPEEQAKFYAPEAAAGPEERGRTRPSFA 120
121 PESSLAPAVAALKAAKYDYAGVGRATPGSTTLLQGAPCAPGFKDDTKGPLNLNMTVQAAG 180
181 VASCLRPSLPDGLPWGAAPGRARKKRKPYTKQQIAELENEFLVNEFINRQKRKELSNRLN 240
241 LSDQQVKIWFQNRRMKKKRVVLREQALALY
Interface Residues: 163, 164, 165, 168, 169, 174, 178, 203, 204, 205, 206, 207, 244, 245, 247, 248, 251, 252, 255, 256, 259
3D-footprint Homologues: 1e3o_C, 1puf_A, 6a8r_A, 3cmy_A, 3d1n_M, 1fjl_B, 5zfz_A, 1ig7_A, 2h1k_B, 3lnq_A, 2lkx_A, 1nk2_P, 1zq3_P, 6es3_K, 2ld5_A, 7q3o_C, 1jgg_B, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 4xrs_G, 2hos_A, 4cyc_A, 7psx_B, 1b72_A, 5flv_I, 5zjt_E, 4j19_B, 3a01_E, 5hod_A, 3l1p_A, 7xrc_C, 1au7_A, 2xsd_C, 1le8_A, 4qtr_D, 1mnm_C, 1k61_B, 8g87_X, 1o4x_A, 1le8_B, 1du0_A
Binding Motifs: MA0873.1 rgTCGTAAAAm
MA1958.1 rrsCGGAAGTyGTAAAa
MA0873.2 rgTCGTAAAA
MA1958.2 CGGAAGTyGTAAA
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]

Guturu H, Doxey AC, Wenger AM, Bejerano G. Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements. Philos Trans R Soc Lond B Biol Sci 368:20130029 (2013). [Pubmed]
Related annotations: PaperBLAST

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