Transcription Factor

						

			
Accessions: P20264 (JASPAR 2024)

			
Names: Brain-1, Brain-specific homeobox/POU domain protein 1, Brn-1, Oct-8, Octamer-binding protein 8, Octamer-binding transcription factor 8, OTF-8, PO3F3_HUMAN, POU domain, class 3, transcription factor 3
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 500
Pfam Domains:   315-388 Pou domain - N-terminal to homeobox domain
  407-463 Homeobox domain
Sequence: 
(in bold interface residues)		   1 MATAASNPYLPGNSLLAAGSIVHSDAAGAGGGGGGGGGGGGGGAGGGGGGMQPGSAAVTS   60
  61 GAYRGDPSSVKMVQSDFMQGAMAASNGGHMLSHAHQWVTALPHAAAAAAAAAAAAVEASS  120
 121 PWSGSAVGMAGSPQQPPQPPPPPPQGPDVKGGAGRDDLHAGTALHHRGPPHLGPPPPPPH  180
 181 QGHPGGWGAAAAAAAAAAAAAAAAHLPSMAGGQQPPPQSLLYSQPGGFTVNGMLSAPPGP  240
 241 GGGGGGAGGGAQSLVHPGLVRGDTPELAEHHHHHHHHAHPHPPHPHHAQGPPHHGGGGGG  300
 301 AGPGLNSHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTI  360
 361 CRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGA  420
 421 LESHFLKCPKPSAQEITNLADSLQLEKEVVRVWFCNRRQKEKRMTPPGIQQQTPDDVYSQ  480
 481 VGTVSADTPPPHHGLQTSVQ
Interface Residues: 340, 356, 357, 358, 359, 361, 362, 368, 372, 405, 407, 408, 409, 410, 448, 449, 451, 452, 455, 456, 459, 460, 463, 469, 472
3D-footprint Homologues: 3d1n_M, 7u0g_M, 3l1p_A, 1o4x_A, 8g87_X, 2xsd_C, 1e3o_C, 7xrc_C, 1au7_A, 3lnq_A, 1fjl_B, 3cmy_A, 2h1k_B, 5zjt_E, 1puf_A, 1ig7_A, 6a8r_A, 5zfz_A, 2lkx_A, 1jgg_B, 1nk2_P, 1zq3_P, 2ld5_A, 1b72_A, 3rkq_B, 2r5y_A, 5hod_A, 1puf_B, 4xrs_G, 3a01_E, 5jlw_D, 1le8_A, 7q3o_C, 7psx_B, 5flv_I, 2hdd_A, 1mnm_C, 1du0_A, 4cyc_A, 6es3_K, 1k61_B
Binding Motifs: MA0788.1 wwTATGCwAATtw
			
Publications: Rhee J. M., Gruber C. A., Brodie T. B., Trieu M., Turner E. E. Highly cooperative homodimerization is a conserved property of neural POU proteins. J. Biol. Chem. 273:34196-34205 (1998). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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