Transcription Factor
Accessions: | MEF2C_HUMAN (HOCOMOCO 10), Q06413 (JASPAR 2024) |
Names: | MEF2C_HUMAN, Myocyte enhancer factor 2C, Myocyte-specific enhancer factor 2C |
Organisms: | Homo sapiens |
Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Length: | 473 |
Pfam Domains: | 10-59 SRF-type transcription factor (DNA-binding and dimerisation domain) 95-155 Holliday junction regulator protein family C-terminal repeat |
Sequence: (in bold interface residues) | 1 MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYAST 60 61 DMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKI 120 121 NEDIDLMISRQRLCAVPPPNFEMPVSIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRN 180 181 SMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNMQAKS 240 241 PPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVAT 300 301 PTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPP 360 361 SALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSP 420 421 VDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT |
Interface Residues: | 3, 4, 15, 18, 19, 23 |
3D-footprint Homologues: | 1n6j_A, 1c7u_A, 7x1n_C, 1hbx_A, 1mnm_A |
Binding Motifs: | MEF2C_HUMAN.H10MO.C|M01321 dkCTATTTTTrgm MA0497.1 rdkcyAAAAATAGmw MA0497.2 cyAAAAATAGm |
Binding Sites: | MA0497.1.1 MA0497.1.10 MA0497.1.11 MA0497.1.12 MA0497.1.13 MA0497.1.14 MA0497.1.15 MA0497.1.16 MA0497.1.17 MA0497.1.18 MA0497.1.19 MA0497.1.2 MA0497.1.20 MA0497.1.3 MA0497.1.4 MA0497.1.5 MA0497.1.6 MA0497.1.7 MA0497.1.8 MA0497.1.9 MA0497.2.1 MA0497.2.10 MA0497.2.11 MA0497.2.12 MA0497.2.13 MA0497.2.14 MA0497.2.15 MA0497.2.16 MA0497.2.17 MA0497.2.18 MA0497.2.19 MA0497.2.2 MA0497.2.20 MA0497.2.3 MA0497.2.4 MA0497.2.5 MA0497.2.6 MA0497.2.7 MA0497.2.8 MA0497.2.9 |
Publications: | Andres V., Cervera M., Mahdavi V. Determination of the consensus binding site for MEF2 expressed in muscle and brain reveals tissue-specific sequence constraints. J. Biol. Chem. 270:23246-23249 (1995). [Pubmed] |
Related annotations: | PaperBLAST |
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