Transcription Factor
| Accessions: | P42580 (JASPAR 2024) |
| Names: | Homeobox protein SAX-1, NK1 transcription factor-related protein 2, NKX-1.1, NKX12_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 305 |
| Pfam Domains: | 157-213 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MLAWQDVGAKAAPSHHKISFSVLDILDPQKFTRAALPPVRLAALEAKKSLEEVEAGQDAC 60 61 SGNPIGSQETPDAVGRGIDPGSPVEGSEAEEEEEAEDAGRAHQPERWQGVHEGSPEARAV 120 121 AVGTEESGAEGLPASPGSPGSPRPRRRRAESSCAKPRRARTAFTYEQLVALENKFRATRY 180 181 LSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGADGAVQAGGGAPQPGTPGAVAGG 240 241 GGSATGSSPGPPVPGALPYQTFPTYPATNVLFPAASFPLTTAANGSPFTPFLGPSYLTPF 300 301 YAPHL |
| Interface Residues: | 157, 158, 159, 160, 161, 198, 199, 201, 202, 205, 206, 209, 210, 213 |
| 3D-footprint Homologues: | 1ig7_A, 2h1k_B, 5zfz_A, 1puf_A, 3cmy_A, 3d1n_M, 1fjl_B, 6a8r_A, 2lkx_A, 1jgg_B, 6m3d_C, 1mnm_C, 1nk2_P, 1zq3_P, 3lnq_A, 2ld5_A, 6es3_K, 7q3o_C, 4xrs_G, 3a01_E, 3rkq_B, 5flv_I, 2hdd_A, 5zjt_E, 4cyc_A, 2r5y_A, 1puf_B, 7psx_B, 5hod_A, 2hos_A, 1b72_A, 5jlw_D, 7xrc_C, 1e3o_C, 1au7_A, 2xsd_C, 1le8_A, 1o4x_A, 1le8_B, 1du0_A, 1k61_B, 4qtr_D |
| Binding Motifs: | PH0110.1 dtbcryYAATTRrtrcw |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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