Transcription Factor
| Accessions: | COT1_HUMAN (HOCOMOCO 10), P10589 (JASPAR 2024) |
| Names: | COT1_HUMAN, COUP transcription factor 1, COUP transcription factor I, COUP-TF I, COUP-TF1, EAR-3, Nuclear receptor subfamily 2 group F member 1, V-erbA-related protein 3 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 423 |
| Pfam Domains: | 85-153 Zinc finger, C4 type (two domains) 205-393 Ligand-binding domain of nuclear hormone receptor |
| Sequence: (in bold interface residues) | 1 MAMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGGAGEQQQQAGSGAPHTPQTPGQPGA 60 61 PATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTY 120 121 TCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLN 180 181 GHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFF 240 241 PDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIR 300 301 IFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQY 360 361 PNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSI 420 421 QCS |
| Interface Residues: | 94, 95, 97, 98, 104, 105, 107, 108, 111, 112, 136, 158, 160, 162 |
| 3D-footprint Homologues: | 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B |
| Binding Motifs: | MA0017.1 TGAmCTTTGmmCyt MA0017.2 carRGGTCAmrrG MA1537.1 rrGGTCAAAGGTCAm MA1538.1 rrGGTCRtTGACCYy COT1_HUMAN.H10MO.B|M01057 cAaAGGTCA MA0017.3 arRGGTCAmrrG MA1537.2 rGGTCAAAGGTCA |
| Binding Sites: | MA0017.1.7 MA0017.1.8 MA0017.1.3 MA0017.1.11 MA0017.1.6 MA0017.1.9 MA0017.1.5 MA0017.1.12 MA0017.1.10 MA0017.1.4 MA0017.1.1 / MA0017.1.2 MA0017.1.13 |
| Publications: | Kimura A., Nishiyori A., Murakami T., Tsukamoto T., Hata S., Osumi T., Okamura R., Mori M., Takiguchi M. Chicken ovalbumin upstream promoter-transcription factor (COUP-TF) represses transcription from the promoter of the gene for ornithine transcarbamylase in a manner antagonistic to hepatocyte nuclear factor-4 (HNF-4). J. Biol. Chem. 268:11125-11133 (1993). [Pubmed] Khan SA, Vanden Heuvel JP. Role of nuclear receptors in the regulation of gene expression by dietary fatty acids (review). J Nutr Biochem 14:554-67 (2003). [Pubmed] |
| Related annotations: | PaperBLAST |
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