Transcription Factor

						

			
Accessions: ATF7_DBD (HumanTF 1.0), ATF7 (HT-SELEX2 May2017)

			
Names: Activating transcription factor 7, ATF7, ATF7_HUMAN, cAMP-dependent transcription factor ATF-7, Cyclic AMP-dependent transcription factor ATF-7, Transcription factor ATF-A, ENSG00000170653
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, HT-SELEX2 May2017 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Uniprot: P17544
Notes: Ensembl ID: ENSG00000170653; DNA-binding domain sequence; TF family: bZIP; Clone source: Gene synthesis, TF family: bZIP experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: bZIP experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4
Length: 425
Pfam Domains:   341-394 Basic region leucine zipper
  342-401 bZIP transcription factor
Sequence: 
(in bold interface residues)		   1 GDDRPFVCNAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARTDSVIIADQTPTPTRFLKNC   60
  61 EEVGLFNELASSFEHEFKKAADEDEKKARSRTVAKKLVAAAGPLDMSLPSTPDIKIKEEE  120
 121 PVEVDSSPPDSPASSPCSPPLKEKEVTPKPVLISTPTPTIVRPGSLPLHLGYDPLHPTLP  180
 181 SPTSVITQAPPSNRQMGSPTGSLPLVMHLANGQTMPVLPGPPVQMPSVISLARPVSMVPN  240
 241 IPGIPGPPVNSSGSISPSGHPIPSEAKMRLKATLTHQVSSINGGCGMVVGTASTMVTARP  300
 301 EQSQILIQHPDAPSPAQPQVSPAQPTPSTGGRRRRTVDEDPDERRQRFLERNRAAASRCR  360
 361 QKRKLWVSSLEKKAEELTSQNIQLSNEVTLLRNEVAQLKQLLLAHKDCPVTALQKKTQGY  420
 421 LESPK
Interface Residues: 19, 20, 21, 22, 24, 25, 27, 28, 29, 347, 348, 352, 353, 355, 356, 359, 360
3D-footprint Homologues: 7y3l_A, 6blw_A, 5ei9_F, 2gli_A, 1f2i_J, 7eyi_G, 7y3m_I, 6jnm_A, 5kl3_A, 1g2f_F, 7n5w_A, 5yj3_D, 1ubd_C, 8cuc_F, 2wbs_A, 1mey_C, 6a57_A, 4x9j_A, 8h9h_G, 6wmi_A, 1tf3_A, 2jpa_A, 7x5e_E, 2wt7_B, 4eot_A, 2wt7_A, 5vpe_D, 6mg1_B, 5t01_B, 2dgc_A, 1dh3_C, 5vpe_C, 1nwq_C
Binding Motifs: ATF7_DBD crATGACGTCAYmv
ATF7_2 grTGACGTCAyc
ATF7_methyl_1 kRTGAyGTmATh
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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