Transcription Factor

						

			
Accessions: 1owr_N (3D-footprint 20231221), 2o93_M (3D-footprint 20231221)

			
Names: NF-ATc2, NF-ATp, NFAC2_HUMAN, NFAT pre-existing subunit, NFATc2, Nuclear factor of activated T-cells, cytoplasmic 2, T-cell transcription factor NFAT1, actor of activated T-cells, cytoplasmic 2
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q13469
Length: 284
Pfam Domains:    16-176 Rel homology domain (RHD)
  195-281 IPT/TIG domain
Sequence: 
(in bold interface residues)		   1 VPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPL   60
  61 GLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATID  120
 121 CAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSA  180
 181 HELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQ  240
 241 PNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV
Interface Residues: 27, 29, 30, 32, 33, 36, 126, 143, 176, 177, 178, 207, 208, 240, 270, 271
3D-footprint Homologues: 1p7h_L, 1a66_A, 1imh_C, 2o61_A, 1nfk_A
Binding Motifs: 1owr_N GGAa
2o93_LMO GGGAnnTTCCGnnnnnnnnnTTCC
2o93_M cGGAa
Binding Sites: 1owr_C
1owr_D
2o93_A
2o93_B
			
Publications: Stroud J.C, Chen L. Structure of NFAT bound to DNA as a monomer. Journal of molecular biology 334:1009-22 (2003). [Pubmed]


Bates D.L, Barthel K.K, Wu Y, Kalhor R, Stroud J.C, Giffin M.J, Chen L. Crystal structure of NFAT bound to the HIV-1 LTR tandem kappaB enhancer element. Structure (London, England : 1993) 16:684-94 (2008). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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