Transcription Factor

						

			
Accessions: Q99687 (JASPAR 2024)

			
Names: Homeobox protein Meis3, Meis1-related protein 2, MEIS3_HUMAN
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q99687
Length: 375
Pfam Domains:   264-319 Homeobox domain
  280-319 Homeobox KN domain
Sequence: 
(in bold interface residues)		   1 MARRYDELPHYPGIVDGPAALASFPETVPAVPGPYGPHRPPQPLPPGLDSDGLKREKDEI   60
  61 YGHPLFPLLALVFEKCELATCSPRDGAGAGLGTPPGGDVCSSDSFNEDIAAFAKQVRSER  120
 121 PLFSSNPELDNLMIQAIQVLRFHLLELEKVHDLCDNFCHRYITCLKGKMPIDLVIEDRDG  180
 181 GCREDFEDYPASCPSLPDQNNMWIRDHEDSGSVHLGTPGPSSGGLASQSGDNSSDQGDGL  240
 241 DTSVASPSSGGEDEDLDQERRRNKKRGIFPKVATNIMRAWLFQHLSHPYPSEEQKKQLAQ  300
 301 DTGLTILQVNNWFINARRRIVQPMIDQSNRTGQGAAFSPEGQPIGGYTETQPHVAVRPPG  360
 361 SVGMSLNLEGEWHYL
Interface Residues: 263, 265, 266, 310, 311, 314, 315, 316, 318, 319
3D-footprint Homologues: 6fqp_B, 2d5v_B, 1puf_B, 4j19_B, 7q3o_C, 1le8_A, 5hod_A, 6fqq_E, 1le8_B, 5zfz_A, 3cmy_A, 1fjl_B, 4xrm_B, 1mnm_C, 6a8r_A, 3lnq_A, 1k61_B, 4xrs_G, 3rkq_B
Binding Motifs: MA0775.1 wTGACAgs
MA0775.2 wTGACAg
			
Publications: Knoepfler P. S., Calvo K. R., Chen H., Antonarakis S. E., Kamps M. P. Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. Proc. Natl. Acad. Sci. USA 94:14553-14558 (1997). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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