Transcription Factor

						

			
Accessions: TFE3_HUMAN (HOCOMOCO 10), P19532 (JASPAR 2024)

			
Names: bHLHe33, Class E basic helix-loop-helix protein 33, TFE3_HUMAN, Transcription factor E3
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P19532
Length: 575
Pfam Domains:   347-400 Helix-loop-helix DNA-binding domain
  432-574 Domain of unknown function (DUF3371)
Sequence: 
(in bold interface residues)		   1 MSHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIVADIELENVLD   60
  61 PDSFYELKSQPLPLRSSLPISLQATPATPATLSASSSAGGSRTPAMSSSSSSRVLLRQQL  120
 121 MRAQAQEQERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQ  180
 181 THLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPT  240
 241 GSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSG  300
 301 NLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRF  360
 361 NINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQAN  420
 421 RSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAATFHVG  480
 481 GGPAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEEGVVGGLSGGA  540
 541 LSPLRAASDPLLSSVSPAVSKASSRRSSFSMEEES
Interface Residues: 348, 351, 352, 354, 355, 358, 359, 383, 385
3D-footprint Homologues: 1a0a_B, 4zpk_A, 7ssa_L, 6g1l_A, 5eyo_A, 1am9_A, 7xi3_A, 5nj8_D, 4h10_A, 7d8t_A, 5gnj_I, 8osl_O, 5v0l_A, 4h10_B, 7f2f_B, 5i50_B, 2ypa_B, 2ypa_A, 8osl_P, 1an4_A, 5nj8_C, 5v0l_B
Binding Motifs: MA0831.1 ryCACGTGay
TFE3_HUMAN.H10MO.C|M01574 rrTCAyGTGg
MA0831.2 CACGTGAy
MA0831.3 rTCACGTGAy
			
Publications: Zhang L, Yu H, Wang P, Ding Q, Wang Z. Screening of transcription factors with transcriptional initiation activity. Gene 531:64-70 (2013). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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