Transcription Factor
| Accessions: | CDX2_DBD (HumanTF 1.0), CDX2 (HT-SELEX2 May2017) |
| Names: | Caudal-type homeobox protein 2, CDX-3, CDX2, CDX2_HUMAN, Homeobox protein CDX-2, ENSG00000165556 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q99626 |
| Notes: | Ensembl ID: ENSG00000165556; DNA-binding domain sequence; TF family: homeodomain; Clone source: Gene synthesis, TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 4b0, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 102 |
| Pfam Domains: | 28-83 Homeobox domain |
| Sequence: (in bold interface residues) | 1 QRRNLCEWMRKPAQQSLGSQVKTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKAELA 60 61 ATLGLSERQVKIWFQNRRAKERKINKKKLQQQQQQQPPQPPP |
| Interface Residues: | 22, 24, 27, 28, 29, 30, 68, 69, 71, 72, 75, 76, 79, 80, 81, 82, 83 |
| 3D-footprint Homologues: | 2lkx_A, 1puf_A, 3d1n_M, 1jgg_B, 3lnq_A, 1nk2_P, 7q3o_C, 6es3_K, 2ld5_A, 6a8r_A, 3a01_E, 2h1k_B, 5jlw_D, 4xrs_G, 3cmy_A, 2hdd_A, 1fjl_B, 5zfz_A, 3rkq_B, 2r5y_A, 6m3d_C, 5flv_I, 2hos_A, 1ig7_A, 4cyc_A, 2d5v_B, 7psx_B, 1e3o_C, 1au7_A, 7xrc_C, 1le8_A, 2xsd_C, 4qtr_D, 1mnm_C, 1puf_B, 1k61_B, 1zq3_P, 1b72_A, 1o4x_A, 8g87_X, 5zjt_E, 1le8_B, 1du0_A, 5hod_A, 3l1p_A |
| Binding Motifs: | CDX2_DBD gymATAAAa CDX2_2 gymATwamc CDX2_3 brtyrTAAay CDX2_methyl_1 srTCGTAamysb |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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