Transcription Factor

						

			
Accessions: O60422 (JASPAR 2024)

			
Names: OC-3, One cut domain family member 3, One cut homeobox 3, ONEC3_HUMAN, Transcription factor ONECUT-3
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: O60422
Length: 494
Pfam Domains:   317-394 CUT domain
  415-468 Homeobox domain
Sequence: 
(in bold interface residues)		   1 MELSLESLGGLHSVAHAQAGELLSPGHARSAAAQHRGLVAPGRPGLVAGMASLLDGGGGG   60
  61 GGGGAGGAGGAGSAGGGADFRGELAGPLHPAMGMACEAPGLGGTYTTLTPLQHLPPLAAV  120
 121 ADKFHQHAAAAAVAGAHGGHPHAHPHPAAAPPPPPPPQRLAASVSGSFTLMRDERAALAS  180
 181 VGHLYGPYGKELPAMGSPLSPLPNALPPALHGAPQPPPPPPPPPLAAYGPPGHLAGDKLL  240
 241 PPAAFEPHAALLGRAEDALARGLPGGGGGTGSGGAGSGSAAGLLAPLGGLAAAGAHGPHG  300
 301 GGGGPGGSGGGPSAGAAAEEINTKEVAQRITAELKRYSIPQAIFAQRILCRSQGTLSDLL  360
 361 RNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEQQKERALQPKKQRLV  420
 421 FTDLQRRTLIAIFKENKRPSKEMQVTISQQLGLELNTVSNFFMNARRRCMNRWAEEPSTA  480
 481 PGGPAGATATFSKA
Interface Residues: 345, 346, 347, 348, 350, 351, 352, 353, 355, 357, 358, 361, 365, 390, 391, 396, 400, 416, 417, 418, 459, 460, 463, 464, 467, 468
3D-footprint Homologues: 3l1p_A, 1au7_A, 2d5v_B, 2o4a_A, 1e3o_C, 2lkx_A, 7q3o_C, 6es3_K, 2hdd_A, 2hos_A, 5hod_A, 1o4x_A, 8g87_X, 4qtr_D, 1puf_B, 6fqp_B, 4xrm_B, 6fqq_E
Binding Motifs: MA0757.1 aaAAAATCrATAaw
MA0757.2 aAAAATCrATAa
			
Publications: Samadani U., Costa R. H. The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression. Mol. Cell. Biol. 16:6273-6284 (1996). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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