Transcription Factor
Accessions: | NR1H4 (SMILE-seq 1.0) |
Names: | Fragment, NR1H4, NR1H4 protein, Q6IPQ7_HUMAN |
Organisms: | Homo sapiens |
Libraries: | SMILE-seq 1.0 1 1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed] |
Uniprot: | Q6IPQ7 |
Notes: | TF family: Nuclear Receptor |
Length: | 475 |
Pfam Domains: | 126-192 Zinc finger, C4 type (two domains) 281-453 Ligand-binding domain of nuclear hormone receptor |
Sequence: (in bold interface residues) | 1 MGSKMNLIEHSHLPTTDEFSFSENLFGVLTEQVAGPLGQNLEVEPYSQYSNVQFPQVQPQ 60 61 ISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTKKPRMGASAGR 120 121 IKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQ 180 181 ECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTT 240 241 KSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQ 300 301 VLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSG 360 361 ISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQ 420 421 KLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDV |
Interface Residues: | 135, 136, 138, 139, 145, 146, 148, 149, 152, 153, 177, 211, 213, 214, 234, 333, 339, 343, 355 |
3D-footprint Homologues: | 6fbq_A, 6l6q_B, 7wnh_D, 1a6y_A, 3g9m_B, 1lo1_A, 4oln_B, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_B, 1kb2_B, 2a66_A, 8hbm_B, 5krb_G, 2nll_B, 1lat_A, 2ff0_A, 1dsz_A, 7xv6_B, 2han_A, 1hcq_E, 1r4i_A, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 2vw9_A |
Binding Motifs: | NR1H4 kaGgTCAwhkd NR1H4_RXRA_1 grGGTcAarGgky NR1H4_RXRA_2 grGkTCAtTGACCyy |
Publications: | Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed] |
Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.