Transcription Factor

Accessions: NR1H4 (SMILE-seq 1.0)
Names: Fragment, NR1H4, NR1H4 protein, Q6IPQ7_HUMAN
Organisms: Homo sapiens
Libraries: SMILE-seq 1.0 1
1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Uniprot: Q6IPQ7
Notes: TF family: Nuclear Receptor
Length: 475
Pfam Domains: 126-192 Zinc finger, C4 type (two domains)
281-453 Ligand-binding domain of nuclear hormone receptor
Sequence:
(in bold interface residues)
1 MGSKMNLIEHSHLPTTDEFSFSENLFGVLTEQVAGPLGQNLEVEPYSQYSNVQFPQVQPQ 60
61 ISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTKKPRMGASAGR 120
121 IKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQ 180
181 ECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTT 240
241 KSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQ 300
301 VLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSG 360
361 ISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQ 420
421 KLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDV
Interface Residues: 135, 136, 138, 139, 145, 146, 148, 149, 152, 153, 177, 211, 213, 214, 234, 333, 339, 343, 355
3D-footprint Homologues: 6fbq_A, 6l6q_B, 7wnh_D, 1a6y_A, 3g9m_B, 1lo1_A, 4oln_B, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_B, 1kb2_B, 2a66_A, 8hbm_B, 5krb_G, 2nll_B, 1lat_A, 2ff0_A, 1dsz_A, 7xv6_B, 2han_A, 1hcq_E, 1r4i_A, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 2vw9_A
Binding Motifs: NR1H4 kaGgTCAwhkd
NR1H4_RXRA_1 grGGTcAarGgky
NR1H4_RXRA_2 grGkTCAtTGACCyy
Publications: Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.