Transcription Factor

Accessions: OCT4 (SMILE-seq 1.0)
Names: Oct-3, Oct-4, OCT4, Octamer-binding protein 3, Octamer-binding protein 4, Octamer-binding transcription factor 3, OTF-3, PO5F1_HUMAN, POU domain, class 5, transcription factor 1
Organisms: Homo sapiens
Libraries: SMILE-seq 1.0 1
1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Uniprot: Q01860
Notes: TF family: HMG
Length: 359
Pfam Domains: 141-212 Pou domain - N-terminal to homeobox domain
231-287 Homeobox domain
Sequence:
(in bold interface residues)
1 MAGHLASDFAFSPPPGGGGDGPGGPEPGWVDPRTWLSFQGPPGGPGIGPGVGPGSEVWGI 60
61 PPCPPPYEFCGGMAYCGPQVGVGLVPQGGLETSQPEGEAGVGVESNSDGASPEPCTVTPG 120
121 AVKLEKEKLEQNPEESQDIKALQKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFS 180
181 QTTICRFEALQLSFKNMCKLRPLLQKWVEEADNNENLQEICKAETLVQARKRKRTSIENR 240
241 VRGNLENLFLQCPKPTLQQISHIAQQLGLEKDVVRVWFCNRRQKGKRSSSDYAQREDFEA 300
301 AGSPFSGGPVSFPLAPGPHFGTPGYGSPHFTALYSSVPFPEGEAFPPVSVTTLGSPMHS
Interface Residues: 164, 180, 181, 182, 183, 185, 186, 192, 196, 230, 231, 232, 233, 234, 235, 272, 275, 276, 279, 280, 282, 283, 284, 287
3D-footprint Homologues: 3d1n_M, 7u0g_M, 3l1p_A, 8g87_X, 1e3o_C, 1au7_A, 2xsd_C, 1o4x_A, 7xrc_C, 3a01_E, 1puf_A, 3cmy_A, 2h1k_B, 1fjl_B, 6a8r_A, 1ig7_A, 5zfz_A, 1jgg_B, 6m3d_C, 3lnq_A, 2lkx_A, 1zq3_P, 7q3o_C, 1nk2_P, 6es3_K, 5hod_A, 3rkq_B, 2r5y_A, 1puf_B, 2hdd_A, 1b72_A, 4xrs_G, 2hos_A, 5jlw_D, 1le8_A, 4cyc_A, 2d5v_B, 5flv_I, 5zjt_E, 4qtr_D, 4xrm_B, 1du0_A, 3vw3_H
Binding Motifs: OCT4 aATTwrCATAww
Publications: Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.