Transcription Factor
Accessions: | OCT4 (SMILE-seq 1.0) |
Names: | Oct-3, Oct-4, OCT4, Octamer-binding protein 3, Octamer-binding protein 4, Octamer-binding transcription factor 3, OTF-3, PO5F1_HUMAN, POU domain, class 5, transcription factor 1 |
Organisms: | Homo sapiens |
Libraries: | SMILE-seq 1.0 1 1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed] |
Uniprot: | Q01860 |
Notes: | TF family: HMG |
Length: | 359 |
Pfam Domains: | 141-212 Pou domain - N-terminal to homeobox domain 231-287 Homeobox domain |
Sequence: (in bold interface residues) | 1 MAGHLASDFAFSPPPGGGGDGPGGPEPGWVDPRTWLSFQGPPGGPGIGPGVGPGSEVWGI 60 61 PPCPPPYEFCGGMAYCGPQVGVGLVPQGGLETSQPEGEAGVGVESNSDGASPEPCTVTPG 120 121 AVKLEKEKLEQNPEESQDIKALQKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFS 180 181 QTTICRFEALQLSFKNMCKLRPLLQKWVEEADNNENLQEICKAETLVQARKRKRTSIENR 240 241 VRGNLENLFLQCPKPTLQQISHIAQQLGLEKDVVRVWFCNRRQKGKRSSSDYAQREDFEA 300 301 AGSPFSGGPVSFPLAPGPHFGTPGYGSPHFTALYSSVPFPEGEAFPPVSVTTLGSPMHS |
Interface Residues: | 164, 180, 181, 182, 183, 185, 186, 192, 196, 230, 231, 232, 233, 234, 235, 272, 275, 276, 279, 280, 282, 283, 284, 287 |
3D-footprint Homologues: | 3d1n_M, 7u0g_M, 3l1p_A, 8g87_X, 1e3o_C, 1au7_A, 2xsd_C, 1o4x_A, 7xrc_C, 3a01_E, 1puf_A, 3cmy_A, 2h1k_B, 1fjl_B, 6a8r_A, 1ig7_A, 5zfz_A, 1jgg_B, 6m3d_C, 3lnq_A, 2lkx_A, 1zq3_P, 7q3o_C, 1nk2_P, 6es3_K, 5hod_A, 3rkq_B, 2r5y_A, 1puf_B, 2hdd_A, 1b72_A, 4xrs_G, 2hos_A, 5jlw_D, 1le8_A, 4cyc_A, 2d5v_B, 5flv_I, 5zjt_E, 4qtr_D, 4xrm_B, 1du0_A, 3vw3_H |
Binding Motifs: | OCT4 aATTwrCATAww |
Publications: | Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.