Transcription Factor
| Accessions: | Q8NBF1 (JASPAR 2024) |
| Names: | GLI-similar 1, GLIS1_HUMAN, Zinc finger protein GLIS1 |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 620 |
| Pfam Domains: | 249-275 Zinc-finger double domain 264-286 C2H2-type zinc finger 264-286 Zinc finger, C2H2 type 278-305 Zinc-finger double domain 292-316 C2H2-type zinc finger 293-316 Zinc finger, C2H2 type 322-346 Zinc finger, C2H2 type 322-346 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MAEARTSLSAHCRGPLATGLHPDLDLPGRSLATPAPSCYLLGSEPSSGLGLQPETHLPEG 60 61 SLKRCCVLGLPPTSPASSSPCASSDVTSIIRSSQTSLVTCVNGLRSPPLTGDLGGPSKRA 120 121 RPGPASTDSHEGSLQLEACRKASFLKQEPADEFSELFGPHQQGLPPPYPLSQLPPGPSLG 180 181 GLGLGLAGRVVAGRQACRWVDCCAAYEQQEELVRHIEKSHIDQRKGEDFTCFWAGCVRRY 240 241 KPFNARYKLLIHMRVHSGEKPNKCMFEGCSKAFSRLENLKIHLRSHTGEKPYLCQHPGCQ 300 301 KAFSNSSDRAKHQRTHLDTKPYACQIPGCSKRYTDPSSLRKHVKAHSAKEQQVRKKLHAG 360 361 PDTEADVLTECLVLQQLHTSTQLAASDGKGGCGLGQELLPGVYPGSITPHNGLASGLLPP 420 421 AHDVPSRHHPLDATTSSHHHLSPLPMAESTRDGLGPGLLSPIVSPLKGLGPPPLPPSSQS 480 481 HSPGGQPFPTLPSKPSYPPFQSPPPPPLPSPQGYQGSFHSIQSCFPYGDCYRMAEPAAGG 540 541 DGLVGETHGFNPLRPNGYHSLSTPLPATGYEALAEASCPTALPQQPSEDVVSSGPEDCGF 600 601 FPNGAFDHCLGHIPSIYTDT |
| Interface Residues: | 208, 210, 211, 214, 243, 244, 245, 246, 247, 248, 249, 250, 251, 253, 254, 255, 257, 274, 275, 276, 277, 278, 280, 281, 285, 304, 305, 306, 307, 308, 309, 310, 311, 312, 334, 335, 336, 337, 338, 339, 340, 341, 342 |
| 3D-footprint Homologues: | 1tf6_A, 5yel_A, 2i13_A, 6wmi_A, 6jnm_A, 3uk3_C, 8cuc_F, 5v3j_F, 2gli_A, 1ubd_C, 5ei9_F, 6e94_A, 7w1m_H, 5k5i_A, 7n5w_A, 5kkq_D, 8h9h_G, 8ssq_A, 7eyi_G, 6a57_A, 8ssu_A, 2jpa_A, 1tf3_A, 7y3l_A, 6ml4_A, 8gn3_A, 1g2f_F, 6blw_A, 6u9q_A, 4x9j_A, 1llm_D, 5kl3_A, 2wbs_A, 7ysf_A, 1mey_C, 5und_A, 1f2i_J, 2kmk_A, 2lt7_A, 7y3m_I, 7txc_E, 5yj3_D, 2drp_D, 4m9v_C |
| Binding Motifs: | MA0735.1 mGACCCCCCACGWwGc MA0735.2 mGACCCCCCACGWwG |
| Publications: | Lichti-Kaiser K, ZeRuth G, Kang HS, Vasanth S, Jetten AM. Gli-similar proteins: their mechanisms of action, physiological functions, and roles in disease. Vitam Horm : (2012;88:141-71.). [Pubmed] |
| Related annotations: | PaperBLAST |
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