Transcription Factor
| Accessions: | T111993_1.02 (CISBP 1.02), UP00326A (UniPROBE 20160601), P11746 (JASPAR 2024) |
| Names: | MCM1, T111993_1.02;, FUN80, GRM/PRTF protein, Pheromone receptor transcription factor, YM9532.08, YMR043W, MCM1_YEAST |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | CISBP 1.02 1, UniPROBE 20160601 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Description: | Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes |
| Notes: | experiment type:PBM, family:MADS box |
| Length: | 286 |
| Pfam Domains: | 24-74 SRF-type transcription factor (DNA-binding and dimerisation domain) |
| Sequence: (in bold interface residues) | 1 MSDIEEGTPTNNGQQKERRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLL 60 61 LVVSETGLVYTFSTPKFEPIVTQQEGRNLIQACLNAPDDEEEDEEEDGDDDDDDDDDGND 120 121 MQRQQPQQQQPQQQQQVLNAHANSLGHLNQDQVPAGALKQEVKSQLLGGANPNQNSMIQQ 180 181 QQHHTQNSQPQQQQQQQPQQQMSQQQMSQHPRPQQGIPHPQQSQPQQQQQQQQQLQQQQQ 240 241 QQQQQPLTGIHQPHQQAFANAASPYLNAEQNAAYQQYFQEPQQGQY |
| Interface Residues: | 15, 18, 19, 30, 33, 34, 38 |
| 3D-footprint Homologues: | 1hbx_A, 1n6j_A, 1c7u_A, 7x1n_C, 1mnm_A |
| Binding Motifs: | MA0331.1 CCyawTyrGGAA UP00326A_1 wstttCCcawwtsGGAmayd M1300_1.02 cgaawwvrGa |
| Binding Sites: | AAAAGGGA AAACGGGA AAAGGGGG AAGGGGGA AATCGGGG AATTGGAA CAAATCGG CCCAAAAA CCGAATTA CCGTTTAG GGGGGAAA TCCCGAAA TTGGGAAA AATGGGGA AGGGGGCA CCAAAAAG GGCAAATA GGGGGACA TCCCAAAA TTCCCAAA |
| Publications: | *Zhu C, *Byers K, *McCord RP, Shi Z, Berger MF, Newburger D, Saulrieta K, Smith Z, Shah M, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A , Murthy TVS, LaBaer J, Bulyk ML. High-Resolution DNA Binding Specificity Analysis of Yeast Transcription Factors. Genome Research. Epub January 21, 2009, doi:10.1101/gr.090233.108 (*co-1st authors). [Pubmed] Pachkov M, Erb I, Molina N, van Nimwegen E. SwissRegulon: a database of genome-wide annotations of regulatory sites. Nucleic acids research 35:D127-31 (2007). [Pubmed] |
| Related annotations: | PaperBLAST |
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