Transcription Factor
Accessions: | SP3_HUMAN (HOCOMOCO 10), Q02447 (JASPAR 2024) |
Names: | SP3_HUMAN, SPR-2, Transcription factor Sp3 |
Organisms: | Homo sapiens |
Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Length: | 781 |
Pfam Domains: | 621-645 Zinc finger, C2H2 type 621-645 C2H2-type zinc finger 637-664 Zinc-finger double domain 651-675 Zinc finger, C2H2 type 651-675 C2H2-type zinc finger 668-690 Zinc-finger double domain 681-703 C2H2-type zinc finger 681-703 Zinc finger, C2H2 type |
Sequence: (in bold interface residues) | 1 MTAPEKPVKQEEMAALDVDSGGGGGGGGGHGEYLQQQQQHGNGAVAAAAAAQDTQPSPLA 60 61 LLAATCSKIGPPSPGDDEEEAAAAAGAPAAAGATGDLASAQLGGAPNRWEVLSATPTTIK 120 121 DEAGNLVQIPSAATSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSSVQYQVIPQIQSAD 180 181 GQQVQIGFTGSSDNGGINQESSQIQIIPGSNQTLLASGTPSANIQNLIPQTGQVQVQGVA 240 241 IGGSSFPGQTQVVANVPLGLPGNITFVPINSVDLDSLGLSGSSQTMTAGINADGHLINTG 300 301 QAMDSSDNSERTGERVSPDINETNTDTDLFVPTSSSSQLPVTIDSTGILQQNTNSLTTSS 360 361 GQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQESQQPTSQAQIVQGITPQT 420 421 IHGVQASGQNISQQALQNLQLQLNPGTFLIQAQTVTPSGQVTWQTFQVQGVQNLQNLQIQ 480 481 NTAAQQITLTPVQTLTLGQVAAGGAFTSTPVSLSTGQLPNLQTVTVNSIDSAGIQLHPGE 540 541 NADSPADIRIKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVAC 600 601 TCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFVCNWMYCGK 660 661 RFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKGIHSSSTVLASVE 720 721 AARDDTLITAGGTTLILANIQQGSVSGIGTVNTSATSNQDILTNTEIPLQLVTVSGNETM 780 781 E |
Interface Residues: | 609, 611, 612, 613, 614, 616, 617, 620, 633, 634, 635, 636, 637, 639, 640, 642, 643, 646, 662, 663, 664, 665, 666, 667, 669, 670, 671, 674, 691, 692, 693, 694, 695, 696, 697, 698, 699, 702, 722, 723, 725, 747, 750 |
3D-footprint Homologues: | 7eyi_G, 7w1m_H, 5v3j_F, 2i13_A, 6ml4_A, 5yel_A, 1tf3_A, 6jnm_A, 8cuc_F, 7n5w_A, 5ei9_F, 1mey_C, 5kl3_A, 7ysf_A, 5k5i_A, 2kmk_A, 8ssq_A, 5und_A, 2gli_A, 1g2f_F, 5k5l_F, 8ssu_A, 1tf6_A, 4x9j_A, 8gn3_A, 6blw_A, 5kkq_D, 1ubd_C, 6u9q_A, 8h9h_G, 6e94_A, 6wmi_A, 2lt7_A, 7y3m_I, 6a57_A, 2jpa_A, 3uk3_C, 7y3l_A, 7txc_E, 2drp_D, 1f2i_J, 1llm_D, 2wbs_A, 4m9v_C, 5yj3_D |
Binding Motifs: | MA0746.1 sCCACrCCCmc MA0746.2 srCCACGCCCmCy SP3_HUMAN.H10MO.B|M01526 gggrggGGGcGGGGcsrgsg MA0746.3 rCCACGCCCmC |
Publications: | Yokoyama KD, Pollock DD. SP transcription factor paralogs and DNA-binding sites coevolve and adaptively converge in mammals and birds. Genome Biol Evol : (2012;4(11):1102-17.). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.