Transcription Factor
| Accessions: | ESR1_HUMAN (HOCOMOCO 10), P03372 (JASPAR 2024) |
| Names: | ER, ER-alpha, ESR1_HUMAN, Estradiol receptor, Estrogen receptor, Nuclear receptor subfamily 3 group A member 1 |
| Organisms: | Homo sapiens, Oryctolagus cuniculus, Rattus norvegicus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 595 |
| Pfam Domains: | 42-181 Oestrogen receptor 184-252 Zinc finger, C4 type (two domains) 328-524 Ligand-binding domain of nuclear hormone receptor 552-595 Oestrogen-type nuclear receptor final C-terminal |
| Sequence: (in bold interface residues) | 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY 60 61 EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF 120 121 LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK 180 181 ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC 240 241 RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR 300 301 SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW 360 361 AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG 420 421 MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD 480 481 KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL 540 541 LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV |
| Interface Residues: | 193, 194, 196, 197, 203, 204, 206, 207, 210, 211, 235, 257, 259, 260, 263, 266, 275, 277, 572 |
| 3D-footprint Homologues: | 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1lo1_A, 1a6y_A, 4oln_B, 2han_B, 1lat_A, 2a66_A, 1dsz_A, 2nll_B, 7xv6_B, 2ff0_A, 1hcq_E, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1kb2_B, 8hbm_B, 5krb_G, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 1r4i_A, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1uaa_B |
| Binding Motifs: | MA0112.2 vkscmaGGtCAcccTGaCCy MA0112.3 arGGTCAcsrTGACCTk ESR1_HUMAN.H10MO.A|M01118 ccAGGTCAcmvtGmcCy MA0112.1 ccAGGTCaCcrtGrCCym MA0112.4 rGGTCAcsrTGACCT |
| Binding Sites: | MA0112.1.1 MA0112.1.2 MA0112.1.3 MA0112.1.4 MA0112.1.5 MA0112.1.6 MA0112.1.7 MA0112.1.8 MA0112.1.9 MA0112.2.1 MA0112.2.10 MA0112.2.11 MA0112.2.12 MA0112.2.13 MA0112.2.14 MA0112.2.15 MA0112.2.16 MA0112.2.17 MA0112.2.18 MA0112.2.19 MA0112.2.2 MA0112.2.20 MA0112.2.3 MA0112.2.4 MA0112.2.5 MA0112.2.6 MA0112.2.7 MA0112.2.8 MA0112.2.9 |
| Publications: | Sandelin A, Wasserman W.W. Prediction of nuclear hormone receptor response elements. Molecular endocrinology (Baltimore, Md.) 19:595-606 (2005). [Pubmed] Welboren W.J, van Driel M.A, Janssen-Megens E.M, van Heeringen S.J, Sweep F.C, Span P.N, Stunnenberg H.G. ChIP-Seq of ERalpha and RNA polymerase II defines genes differentially responding to ligands. The EMBO journal 28:1418-28 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.