Transcription Factor
| Accessions: | Q62231 (JASPAR 2024) |
| Names: | Homeobox protein SIX1, Sine oculis homeobox homolog 1, SIX1_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q62231 |
| Length: | 284 |
| Pfam Domains: | 131-180 Homeobox domain 145-178 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 MSMLPSFGFTQEQVACVCEVLQQGGNLERLGRFLWSLPACDHLHKNESVLKAKAVVAFHR 60 61 GNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRT 120 121 IWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDR 180 181 AAEAKERENTENNNSSSNKQNQLSPLEGGKPLMSSSEEEFSPPQSPDQNSVLLLQSNMGH 240 241 ARSSNYSLPGLTASQPSHGLQAHQHQLQDSLLGPLTSSLVDLGS |
| Interface Residues: | 119, 128, 166, 167, 169, 170, 173, 174, 177, 178, 180, 181 |
| 3D-footprint Homologues: | 4xrs_G, 4j19_B, 5jlw_D, 2ld5_A, 1au7_A, 7xrc_C, 1le8_A, 1ig7_A, 2xsd_C, 1e3o_C, 7q3o_C, 1k61_B, 5zjt_E, 4qtr_D, 3cmy_A, 2hdd_A, 1nk2_P, 6fqq_E, 1fjl_B, 5hod_A, 3rkq_B, 2r5y_A, 1zq3_P, 6a8r_A, 1b72_A, 4xrm_B, 3d1n_M, 1o4x_A, 4cyc_A, 2d5v_B, 8g87_X, 1le8_B, 6es3_K, 1du0_A, 3l1p_A, 1puf_A, 7psx_B, 1jgg_B, 5zfz_A, 3a01_E, 2h1k_B, 1mnm_C, 6fqp_B, 5flv_I, 3lnq_A, 2lkx_A, 1puf_B, 2hos_A, 6m3d_C |
| Binding Motifs: | PH0161.1 ratrGGGTATCAykwbt |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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