Transcription Factor

						

			
Accessions: hb (DrosophilaTF 1.1), P05084 (JASPAR 2024)

			
Names: HUNB_DROME
Organisms: Drosophila melanogaster
Libraries: DrosophilaTF 1.1 1, JASPAR 2024 2
1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P05084
Length: 758
Pfam Domains:   255-277 Zinc-finger double domain
  283-308 Zinc-finger double domain
Sequence: 
(in bold interface residues)		   1 MQNWETTATTNYEQHNAWYNSMFAANIKQEPGHHLDGNSVASSPRQSPIPSTNHLEQFLK   60
  61 QQQQQLQQQPMDTLCAMTPSPSQNDQNSLQHYDANLQQQLLQQQQYQQHFQAAQQQHHHH  120
 121 HHLMGGFNPLTPPGLPNPMQHFYGGNLRPSPQPTPTSASTIAPVAVATGSSEKLQALTPP  180
 181 MDVTPPKSPAKSSQSNIEPEKEHDQMSNSSEDMKYMAESEDDDTNIRMPIYNSHGKMKNY  240
 241 KCKTCGVVAITKVDFWAHTRTHMKPDKILQCPKCPFVTEFKHHLEYHIRKHKNQKPFQCD  300
 301 KCSYTCVNKSMLNSHRKSHSSVYQYRCADCDYATKYCHSFKLHLRKYGHKPGMVLDEDGT  360
 361 PNPSLVIDVYGTRRGPKSKNGGPIASGGSGSGSRKSNVAAVAPQQQQSQPAQPVATSQLS  420
 421 AALQGFPLVQGNSAPPAASPVLPLPASPAKSVASVEQTPSLPSPANLLPPLASLLQQNRN  480
 481 MAFFPYWNLNLQMLAAQQQAAVLAQLSPRMREQLQQQNQQQSDNEEEEQDDEYERKSVDS  540
 541 AMDLSQGTPVKEDEQQQQPQQPLAMNLKVEEEATPLMSSSNASRRKGRVLKLDTLLQLRS  600
 601 EAMTSPEQLKVPSTPMPTASSPIAGRKPMPEEHCSGTSSADESMETAHVPQANTSASSTA  660
 661 SSSGNSSNASSNSNGNSSSNSSSNGTTSAVAAPPSGTPAAAGAIYECKYCDIFFKDAVLY  720
 721 TIHMGYHSCDDVFKCNMCGEKCDGPVGLFVHMARNAHS
Interface Residues: 225, 250, 251, 252, 253, 254, 256, 257, 278, 279, 280, 281, 282, 283, 285, 286, 288, 289, 292, 307, 308, 309, 310, 311, 312, 313, 314, 315, 318, 335, 336, 337, 338, 339, 340, 341, 342, 343, 345, 346, 347
3D-footprint Homologues: 5und_A, 8ssu_A, 7w1m_H, 8ssq_A, 1mey_C, 5yel_A, 5ei9_F, 2i13_A, 7ysf_A, 5v3j_F, 2lt7_A, 5kkq_D, 8cuc_F, 7n5w_A, 3uk3_C, 5k5i_A, 6jnm_A, 5k5l_F, 6ml4_A, 4x9j_A, 8gn3_A, 6u9q_A, 7txc_E, 1llm_D, 7eyi_G, 8h9h_G, 1g2f_F, 7y3m_I, 6e94_A, 6wmi_A, 6a57_A, 6blw_A, 5kl3_A, 2jpa_A, 1f2i_J, 7y3l_A, 2wbs_A, 5yj3_D, 4m9v_C, 1tf3_A
Binding Motifs: MA0049.1 smrwAAAAAa
hb smATAAAAAA
Binding Sites: MA0049.1.8
MA0049.1.15
MA0049.1.5
MA0049.1.1
MA0049.1.3
MA0049.1.7
MA0049.1.11
MA0049.1.12
MA0049.1.13
MA0049.1.14
MA0049.1.2
MA0049.1.4
MA0049.1.16
MA0049.1.9
MA0049.1.6
MA0049.1.10
			
Publications: Stanojevic D., Hoey T., Levine M. Sequence-specific DNA-binding activities of the gap proteins encoded by hunchback and Krueppel in Drosophila. Nature 341:331-335 (1989). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.