Transcription Factor
| Accessions: | T018418_1.02 (CISBP 1.02), UP00332A (UniPROBE 20160601), P07270 (JASPAR 2024) |
| Names: | PHO4, T018418_1.02;, Phosphate system positive regulatory protein PHO4, YFR034C, PHO4_YEAST |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | CISBP 1.02 1, UniPROBE 20160601 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P07270 |
| Description: | Basic helix-loop-helix (bHLH) transcription factor; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability |
| Notes: | experiment type:PBM, family:bHLH |
| Length: | 312 |
| Pfam Domains: | 251-307 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MGRTTSEGIHGFVDDLEPKSSILDKVGDFITVNTKRHDGREDFNEQNDELNSQENHNSSE 60 61 NGNENENEQDSLALDDLDRAFELVEGMDMDWMMPSHAHHSPATTATIKPRLLYSPLIHTQ 120 121 SAVPVTISPNLVATATSTTSANKVTKNKSNSSPYLNKRRGKPGPDSATSLFELPDSVIPT 180 181 PKPKPKPKQYPKVILPSNSTRRVSPVTAKTSSSAEGVVVASESPVIAPHGSSHSRSLSKR 240 241 RSSGALVDDDKRESHKHAEQARRNRLAVALHELASLIPAEWKQQNVSAAPSKATTVEAAC 300 301 RYIRHLQQNVST |
| Interface Residues: | 60, 252, 254, 255, 256, 258, 259, 262, 263, 290, 292 |
| 3D-footprint Homologues: | 2qkb_A, 1a0a_B, 1an4_A, 6g1l_A, 8osl_O, 4zpk_A, 7d8t_A, 5nj8_D, 7ssa_L, 4h10_A, 5v0l_A, 7xi3_A, 4h10_B, 8osl_P |
| Binding Motifs: | MA0357.1 sCACGTGs UP00332A_1 gwcymasCACGTGsycskhw M0242_1.02 vcCACGTGch |
| Binding Sites: | AACACGTG ACACGTGC ACACGTGG ACACGTGT ACCACGTG AGCACGTG ATCACGTG CACACGTG CACGTGCA CACGTGCC CACGTGCG CACGTGGA CACGTGGC CACGTGGG CACGTGTA CACGTGTC CCACGTGA CCACGTGC CCACGTGG GCACGTGC |
| Publications: | *Zhu C, *Byers K, *McCord RP, Shi Z, Berger MF, Newburger D, Saulrieta K, Smith Z, Shah M, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A , Murthy TVS, LaBaer J, Bulyk ML. High-Resolution DNA Binding Specificity Analysis of Yeast Transcription Factors. Genome Research. Epub January 21, 2009, doi:10.1101/gr.090233.108 (*co-1st authors). [Pubmed] Newburger D.E, Bulyk M.L. UniPROBE: an online database of protein binding microarray data on protein-DNA interactions. Nucleic acids research 37:D77-82 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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