Transcription Factor

Accessions: 1c7u_A (3D-footprint 20231221), 1c7u_B (3D-footprint 20231221)
Names: MEF2A_HUMAN, MYOCYTE-SPECIFIC ENHANCER FACTOR 2A, C4 FORM, Serum response factor-like protein 1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q02078
Length: 74
Pfam Domains: 9-58 SRF-type transcription factor (DNA-binding and dimerisation domain)
Sequence:
(in bold interface residues)
1 GRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLADAEIALIIFNSSNKLFQYASTD 60
61 MDKVLLKYTEYNEP
Interface Residues: 2, 3, 14, 17, 18, 22, 56, 67
3D-footprint Homologues: 1n6j_A, 1c7u_A, 7x1n_C, 1hbx_A, 1mnm_A, 7yq3_E
Binding Motifs: 1c7u_AB CGncTAnnnnTAgnCG
1c7u_B TAgncG
Binding Sites: 1c7u_C / 1c7u_D
Publications: Huang K, Louis J.M, Donaldson L, Lim F.L, Sharrocks A.D, Clore G.M. Solution structure of the MEF2A-DNA complex: structural basis for the modulation of DNA bending and specificity by MADS-box transcription factors. The EMBO journal 19:2615-28 (2000). [Pubmed]
Related annotations: PaperBLAST

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