Transcription Factor
Accessions: | T098548_1.02 (CISBP 1.02), Q95RW8 (JASPAR 2024) |
Names: | Optix, T098548_1.02;, D-Six3, Homeobox protein SIX3, OPTIX_DROME, Protein Optix |
Organisms: | Drosophila melanogaster |
Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Uniprot: | Q95RW8 |
Notes: | experiment type:PBM, family:Homeodomain |
Length: | 487 |
Pfam Domains: | 161-212 Homeobox domain 176-210 Homeobox KN domain |
Sequence: (in bold interface residues) | 1 MAVGPTEGKQPPSESFSPTHHQIIAPSPILAVPTLAFSAAQVEIVCKTLEDSGDIERLAR 60 61 FLWSLPVALPNMHEILNCEAVLRARAVVAYHVGNFRELYAIIENHKFTKASYGKLQAMWL 120 121 EAHYIEAEKLRGRSLGPVDKYRVRKKFPLPPTIWDGEQKTHCFKERTRSLLREWYLQDPY 180 181 PNPTKKRELAKATGLNPTQVGNWFKNRRQRDRAAAAKNRIQHSQNSSGMGCRSRRADGAA 240 241 SPTPSDSSDSDISLGTHSPVPSSLQLQHSPGSTSNGANDREESLSVDDDKPRDLSGSLPL 300 301 PLSLPLPLASPTHTPPQLPPGYGGGAGAGPGGPLTGPGCLPPFKLDAATSLFSAGCYLQS 360 361 FSNLKEMSQQFPIQPIVLRPHPQLPQSLALNGASGGPPLHHPAYAAAYSVECVPGGHGPP 420 421 HPPPKLRINSPEKLNSTAVAAAASVGGGGGNQHHEPTTTGYHHSGQLMLHRPFSTSPELK 480 481 HSAPEIT |
Interface Residues: | 151, 159, 160, 161, 162, 198, 199, 201, 202, 205, 206, 209, 210, 212, 213 |
3D-footprint Homologues: | 4xrs_G, 2lkx_A, 2r5y_A, 1jgg_B, 1mnm_C, 3l1p_A, 1puf_B, 1k61_B, 1le8_B, 2ld5_A, 5jlw_D, 4j19_B, 1le8_A, 7q3o_C, 1ig7_A, 7xrc_C, 1e3o_C, 2xsd_C, 1zq3_P, 8g87_X, 6es3_K, 1nk2_P, 7psx_B, 1fjl_B, 5zfz_A, 3a01_E, 2h1k_B, 6fqp_B, 1b72_A, 5flv_I, 3lnq_A, 1puf_A, 5zjt_E, 4qtr_D, 3cmy_A, 2hdd_A, 6fqq_E, 1du0_A, 5hod_A, 3rkq_B, 6a8r_A, 4xrm_B, 3d1n_M, 4cyc_A, 2hos_A, 6m3d_C |
Binding Motifs: | MA0199.1 TGATA M1100_1.02 trrgrgATaw |
Binding Sites: | MA0199.1.1 MA0199.1.10 / MA0199.1.20 MA0199.1.11 MA0199.1.12 MA0199.1.13 MA0199.1.14 MA0199.1.15 MA0199.1.16 MA0199.1.17 MA0199.1.18 MA0199.1.19 MA0199.1.2 MA0199.1.3 MA0199.1.4 MA0199.1.5 MA0199.1.6 MA0199.1.7 MA0199.1.8 MA0199.1.9 |
Publications: | Noyes M.B, Meng X, Wakabayashi A, Sinha S, Brodsky M.H, Wolfe S.A. A systematic characterization of factors that regulate Drosophila segmentation via a bacterial one-hybrid system. Nucleic acids research 36:2547-60 (2008). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.