Transcription Factor
| Accessions: | ZNF317 (humanC2H2ZF-ChIP Feb2015), Q96PQ6 (JASPAR 2024) |
| Names: | ENSG00000130803, Q96PQ6, ZNF317, ZN317_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | humanC2H2ZF-ChIP Feb2015 1, JASPAR 2024 2 1 Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. C2H2 zinc finger proteins greatly expand the human regulatory lexicon. Nat Biotechnol 33:555-62 (2015). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | TF family: C2H2;KRAB experiment: ChIP-seq/MEME/B1H-RC |
| Length: | 595 |
| Pfam Domains: | 57-97 KRAB box 222-242 C2H2-type zinc finger 222-244 Zinc finger, C2H2 type 222-244 C2H2-type zinc finger 236-260 Zinc-finger double domain 249-273 C2H2-type zinc finger 250-272 Zinc finger, C2H2 type 250-272 C2H2-type zinc finger 264-289 Zinc-finger double domain 278-300 Zinc finger, C2H2 type 278-300 C2H2-type zinc finger 279-300 C2H2-type zinc finger 292-316 Zinc-finger double domain 305-328 C2H2-type zinc finger 306-328 Zinc finger, C2H2 type 306-328 C2H2-type zinc finger 321-343 Zinc-finger double domain 333-345 C2H2-type zinc finger 334-356 C2H2-type zinc finger 334-356 Zinc finger, C2H2 type 348-371 Zinc-finger double domain 362-384 C2H2-type zinc finger 362-385 C2H2-type zinc finger 362-384 Zinc finger, C2H2 type 376-399 Zinc-finger double domain 389-404 C2H2-type zinc finger 390-412 Zinc finger, C2H2 type 390-412 C2H2-type zinc finger 406-429 Zinc-finger double domain 419-440 Zinc finger, C2H2 type 419-440 C2H2-type zinc finger 419-440 C2H2-type zinc finger 433-456 Zinc-finger double domain 446-467 C2H2-type zinc finger 446-468 Zinc finger, C2H2 type 448-468 C2H2-type zinc finger 460-483 Zinc-finger double domain 474-488 C2H2-type zinc finger 474-496 C2H2-type zinc finger 490-513 Zinc-finger double domain 503-524 C2H2-type zinc finger 503-524 Zinc finger, C2H2 type 503-524 C2H2-type zinc finger 517-540 Zinc-finger double domain 529-550 C2H2-type zinc finger 530-552 Zinc finger, C2H2 type 544-568 Zinc-finger double domain 557-582 C2H2-type zinc finger 557-581 C2H2 type zinc-finger (2 copies) 558-580 Zinc finger, C2H2 type 558-580 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MAALSPTFATSTQDSTCLQDSEFPVSSKDHSCPQNLDLFVCSGLEPHTPSVGSQESVTFQ 60 61 DVAVDFTEKEWPLLDSSQRKLYKDVMLENYSNLTSLGYQVGKPSLISHLEQEEEPRTEER 120 121 GAHQGACADWETPSKTKWSLLMEDIFGKETPSGVTMERAGLGEKSTEYAHLFEVFGMDPH 180 181 LTQPMGRHAGKRPYHRRDYGVAFKGRPHLTQHMSMYDGRKMHECHQCQKAFTTSASLTRH 240 241 RRIHTGEKPYECSDCGKAFNDPSALRSHARTHLKEKPFDCSQCGNAFRTLSALKIHMRVH 300 301 TGERPYKCDQCGKAYGRSCHLIAHKRTHTGERPYECHDCGKAFQHPSHLKEHVRNHTGEK 360 361 PYACTQCGKAFRWKSNFNLHKKNHMVEKTYECKECGKSFGDLVSRRKHMRIHIVKKPVEC 420 421 RQCGKTFRNQSILKTHMNSHTGEKPYGCDLCGKAFSASSNLTAHRKIHTQERRYECAACG 480 481 KVFGDYLSRRRHMSVHLVKKRVECRQCGKAFRNQSTLKTHMRSHTGEKPYECDHCGKAFS 540 541 IGSNLNVHRRIHTGEKPYECLVCGKAFSDHSSLRSHVKTHRGEKLFVSSVWKRLQ |
| Interface Residues: | 207, 211, 232, 233, 234, 235, 236, 239, 261, 262, 263, 264, 267, 288, 289, 290, 291, 292, 294, 295, 297, 298, 301, 316, 317, 318, 319, 320, 323, 345, 346, 347, 348, 349, 350, 351, 372, 373, 374, 375, 376, 377, 378, 379, 381, 400, 401, 403, 404, 406, 407, 413, 427, 428, 429, 430, 431, 432, 434, 435, 439, 456, 457, 458, 459, 460, 463, 485, 487, 488, 489, 491, 492, 495, 502, 513, 514, 515, 516, 518, 519, 540, 541, 542, 543, 544, 547, 548, 569, 570, 571, 572, 573, 574, 575, 576 |
| 3D-footprint Homologues: | 7w1m_H, 7n5w_A, 2i13_A, 8h9h_G, 7eyi_G, 7ysf_A, 5yel_A, 5ei9_F, 1mey_C, 6wmi_A, 8ssq_A, 8ssu_A, 5kkq_D, 7txc_E, 5und_A, 6blw_A, 6e94_A, 2jpa_A, 1tf3_A, 6jnm_A, 2wbs_A, 5kl3_A, 1f2i_J, 5v3j_F, 4x9j_A, 6a57_A, 2drp_D, 6ml4_A, 1g2f_F, 5k5i_A, 1tf6_A, 1llm_D, 2gli_A, 5yj3_D, 1ubd_C, 2kmk_A, 6u9q_A, 8gn3_A, 7y3m_I, 2lt7_A, 3uk3_C, 8cuc_F, 7y3l_A, 5k5l_F, 4m9v_C |
| Binding Motifs: | ZNF317_ChIP ACAATrG MA1593.1 wrACAGCAGAyw MA1593.2 ACAGCAGA |
| Binding Sites: | MA1593.2.1 / MA1593.2.10 / MA1593.2.16 / MA1593.2.6 / MA1593.2.9 MA1593.1.1 MA1593.1.10 / MA1593.1.9 MA1593.1.10 / MA1593.1.11 MA1593.1.11 / MA1593.1.12 MA1593.1.12 / MA1593.1.13 MA1593.1.13 / MA1593.1.14 MA1593.1.14 / MA1593.1.15 MA1593.1.15 / MA1593.1.16 MA1593.1.16 / MA1593.1.17 MA1593.1.18 MA1593.1.17 / MA1593.1.19 MA1593.1.1 / MA1593.1.2 MA1593.1.18 / MA1593.1.20 MA1593.1.2 / MA1593.1.3 MA1593.1.3 / MA1593.1.4 MA1593.1.4 / MA1593.1.5 MA1593.1.5 / MA1593.1.6 MA1593.1.6 / MA1593.1.7 MA1593.1.7 / MA1593.1.8 MA1593.1.8 / MA1593.1.9 MA1593.1.19 MA1593.1.20 MA1593.2.11 / MA1593.2.12 / MA1593.2.13 / MA1593.2.15 / MA1593.2.17 / MA1593.2.2 / MA1593.2.20 / MA1593.2.4 MA1593.2.14 MA1593.2.18 MA1593.2.19 MA1593.2.3 MA1593.2.5 MA1593.2.7 MA1593.2.8 |
| Publications: | Imbeault M, Helleboid PY, Trono D. KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks. Nature 543:550-554 (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.