Transcription Factor
| Accessions: | LEF1_HUMAN (HOCOMOCO 10), Q9UJU2 (JASPAR 2024) |
| Names: | LEF-1, LEF1_HUMAN, Lymphoid enhancer-binding factor 1, T cell-specific transcription factor 1-alpha, TCF1-alpha |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q9UJU2 |
| Length: | 399 |
| Pfam Domains: | 1-213 N-terminal CTNNB1 binding 294-357 Domain of unknown function (DUF1898) 299-366 HMG (high mobility group) box |
| Sequence: (in bold interface residues) | 1 MPQLSGGGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE 60 61 SEIIPASNGHEVARQAQTSQEPYHDKAREHPDDGKHPDGGLYNKGPSYSSYSGYIMMPNM 120 121 NNDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSDEHFSPGSHPSHIPSDVNS 180 181 KQGMSRHPPAPDIPTFYPLSPGGVGQITPPLGWQGQPVYPITGGFRQPYPSSLSVDTSMS 240 241 RFSHHMIPGPPGPHTTGIPHPAIVTPQVKQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIK 300 301 KPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHM 360 361 QLYPGWSARDNYGKKKKRKREKLQESASGTGPRMTAAYI |
| Interface Residues: | 301, 304, 306, 307, 310, 314, 325, 326, 327, 330, 368, 370, 372, 375, 377, 378, 379, 382 |
| 3D-footprint Homologues: | 4s2q_D, 2lef_A, 4y60_C, 1j5n_A, 3f27_D, 6jrp_D, 1o4x_B, 3u2b_C, 7m5w_A, 2gzk_A, 1hry_A |
| Binding Motifs: | MA0768.1 aAAGATCAAAGgrww LEF1_HUMAN.H10MO.C|M01297 CTTTGww |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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