Transcription Factor
| Accessions: | DLX2_Full (HumanTF2 1.0) |
| Names: | DLX2, DLX2_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF2 1.0 1 1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | Q07687 |
| Notes: | Ensembl ID: ENSG00000115844; Construct type: Full length protein used in HT-SELEX with mixed proteins; TF family: Homeodomain; Clone source: Jolma et al. 2013 |
| Length: | 329 |
| Pfam Domains: | 51-132 Homeobox protein distal-less-like N terminal 153-209 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MTGVFDSLVADMHSTQIAASSTYHQHQQPPSGGGAGPGGNSSSSSSLHKPQESPTLPVST 60 61 ATDSSYYTNQQHPAGGGGGGGSPYAHMGSYQYQASGLNNVPYSAKSSYDLGYTAAYTSYA 120 121 PYGTSSSPANNEPEKEDLEPEIRIVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALP 180 181 ERAELAASLGLTQTQVKIWFQNRRSKFKKMWKSGEIPSEQHPGASASPPCASPPVSAPAS 240 241 WDFGVPQRMAGGGGPGSGGSGAGSSGSSPSSAASAFLGNYPWYHQTSGSASHLQATAPLL 300 301 HPTQTPQPHHHHHHHGGGGAPVSAGTIF* |
| Interface Residues: | 153, 154, 155, 156, 194, 195, 197, 198, 201, 202, 205, 206, 209 |
| 3D-footprint Homologues: | 1puf_A, 1ig7_A, 5zjt_E, 3cmy_A, 1mnm_C, 6a8r_A, 3d1n_M, 1fjl_B, 5zfz_A, 2h1k_B, 2lkx_A, 1nk2_P, 1zq3_P, 6m3d_C, 7q3o_C, 6es3_K, 2ld5_A, 2hdd_A, 7psx_B, 5hod_A, 3rkq_B, 2r5y_A, 1jgg_B, 2hos_A, 5jlw_D, 4cyc_A, 4xrs_G, 4j19_B, 3a01_E, 1b72_A, 5flv_I, 3lnq_A, 1e3o_C, 2xsd_C, 1au7_A, 7xrc_C, 1le8_A, 8g87_X, 4qtr_D, 1du0_A, 1puf_B, 4xrm_B, 1k61_B, 3l1p_A, 1o4x_A |
| Binding Motifs: | ERF_DLX2_1 rsmGGAwrtsrvymaTTA ERF_DLX2_2 rsmGGAwrtsrvymaTTa ETV2_DLX2_1 acCGGAWrTwrmbyAATTR ETV2_DLX2_2 rsMGGAAryvvsyaATTA ETV5_DLX2 rsCGGAwrtvrsymATTA FLI1_DLX2_1 rsMGGAAryaaTtA FLI1_DLX2_2 rvmGGAArtsvsyaaTtar FLI1_DLX2_2_3 ACCGGAArTgrsyAATTA GCM2_DLX2 rTrcGGGywadwtAATtr MEIS1_DLX2 tGACArswTAATtr MGA_DLX2_1 rGGTGhTAATTr MGA_DLX2_2 syAATTAwaGGTGyGA POU2F1_DLX2_1 tgAATATkcaTmCAcTAATTG POU2F1_DLX2_2 tGmATATkCahwmkTAATTr POU2F1_DLX2_2_3 wTwTGCRwAkyYAATtr TEAD4_DLX2_1 rmATwcyargyaATTA TEAD4_DLX2_2 rCATwCyacwryAATTA TEAD4_DLX2_2_3 rmATwcywyssTAATtr TEAD4_DLX2_2_3_4 ggwATGtTAATkr TEAD4_DLX2_2_3_4_5 crCATwCCryvmTAATtrc TEAD4_DLX2_2_3_4_5_6 crCATwCCrvsyaATTA |
| Publications: | Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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