Transcription Factor

Accessions: MYF6 (SMILE-seq 1.0)
Names: bHLHc4, Class C basic helix-loop-helix protein 4, Muscle-specific regulatory factor 4, Myf-6, MYF6, MYF6_HUMAN, Myogenic factor 6
Organisms: Homo sapiens
Libraries: SMILE-seq 1.0 1
1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Uniprot: P23409
Notes: TF family: bHLH
Length: 241
Pfam Domains: 3-93 Myogenic Basic domain
94-145 Helix-loop-helix DNA-binding domain
Sequence:
(in bold interface residues)
1 MMMDLFETGSYFFYLDGENVTLQPLEVAEGSPLYPGSDGTLSPCQDQMPPEAGSDSSGEE 60
61 HVLAPPGLQPPHCPGQCLIWACKTCKRKSAPTDRRKAATLRERRRLKKINEAFEALKRRT 120
121 VANPNQRLPKVEILRSAISYIERLQDLLHRLDQQEKMQELGVDPFSYRPKQENLEGADFL 180
181 RTCSSQWPSVSDHSRGLVITAKEGGASIDSSASSSLRCLSSIVDSISSEERKLPCVEEVV 240
241 E
Interface Residues: 95, 98, 99, 101, 102, 103, 105, 106, 122, 126, 127, 130, 136
3D-footprint Homologues: 7z5k_B, 2ypa_A, 6g1l_A, 6od3_F, 5i50_B, 1am9_A, 2ypa_B, 2ql2_A, 2ql2_D, 7d8t_A, 5gnj_I, 5xut_A
Binding Motifs: MYF6 yaACAgkTGwy
Publications: Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.