Transcription Factor

Accessions: P28359 (JASPAR 2024)
Names: Homeobox protein Hox-4.5, Homeobox protein Hox-5.3, Homeobox protein Hox-D10, HXD10_MOUSE
Organisms: Mus musculus
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P28359
Length: 340
Pfam Domains: 267-323 Homeobox domain
Sequence:
(in bold interface residues)
1 MSFPNSSPAANTFLVDSLISACRSDSFYSSSASMYMPPPSADMGTYGMQTCGLLPSLAKR 60
61 EVNHQNMGMNVHPYIPQVDSWTDPNRSCRIEQPVTQQVPTCSFTANIKEESNCCMYSDKR 120
121 NKLISAEVPSYQRLVPESCPVENPEVPVPGYFRLSQTYATGKTQEYNNSPEGSSTVMLQL 180
181 NPRGAAKPQLSAAQLQMEKKMNESASGQEPTKVSQVESPEAKGGLPEDRSCLAEVSVSSP 240
241 EVQEKESKEEIKSDTPTSNWLTAKSGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLEIS 300
301 KSVNLTDRQVKIWFQNRRMKLKKMSRENRIRELTANLTFS
Interface Residues: 267, 268, 269, 270, 308, 309, 311, 312, 315, 316, 319, 320, 323
3D-footprint Homologues: 6a8r_A, 2h1k_B, 5zfz_A, 1puf_A, 1fjl_B, 6m3d_C, 3cmy_A, 1ig7_A, 3d1n_M, 1zq3_P, 3lnq_A, 2lkx_A, 1nk2_P, 7q3o_C, 2ld5_A, 6es3_K, 1jgg_B, 5jlw_D, 4xrs_G, 3a01_E, 3rkq_B, 5flv_I, 2hdd_A, 1b72_A, 5zjt_E, 4cyc_A, 2r5y_A, 1puf_B, 7psx_B, 2hos_A, 2xsd_C, 1e3o_C, 7xrc_C, 1le8_A, 1du0_A, 4qtr_D, 1o4x_A, 1k61_B, 5hod_A
Binding Motifs: PH0075.1 mrkgyAATAAAAtwwww
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.