Transcription Factor

Accessions: E2F4_HUMAN (HOCOMOCO 10), Q16254 (JASPAR 2024)
Names: E2F-4, E2F4_HUMAN, Transcription factor E2F4
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 413
Pfam Domains: 17-83 E2F/DP family winged-helix DNA-binding domain
Sequence:
(in bold interface residues)
1 MAEAGPQAPPPPGTPSRHEKSLGLLTTKFVSLLQEAKDGVLDLKLAADTLAVRQKRRIYD 60
61 ITNVLEGIGLIEKKSKNSIQWKGVGPGCNTREIADKLIELKAEIEELQQREQELDQHKVW 120
121 VQQSIRNVTEDVQNSCLAYVTHEDICRCFAGDTLLAIRAPSGTSLEVPIPEGLNGQKKYQ 180
181 IHLKSVSGPIEVLLVNKEAWSSPPVAVPVPPPEDLLQSPSAVSTPPPLPKPALAQSQEAS 240
241 RPNSPQLTPTAVPGSAEVQGMAGPAAEITVSGGPGTDSKDSGELSSLPLGPTTLDTRPLQ 300
301 SSALLDSSSSSSSSSSSSSNSNSSSSSGPNPSTSFEPIKADPTGVLELPKELSEIFDPTR 360
361 ECMSSELLEELMSSEVFAPLLRLSPPPGDHDYIYNLDESEGVCDLFDVPVLNL
Interface Residues: 17, 54, 55, 56, 57, 59
3D-footprint Homologues: 1cf7_A, 4yo2_A, 1cf7_B
Binding Motifs: MA0470.1 gsGCGGGArrr
MA0470.2 wTtTGGCGCCawww
E2F4_HUMAN.H10MO.A|M01089 wwwkGGCGsGAAar
MA0470.3 wTtTGGCGCCaww
Binding Sites: MA0470.1.1
MA0470.1.10
MA0470.1.11
MA0470.1.12
MA0470.1.13
MA0470.1.14
MA0470.1.15
MA0470.1.16
MA0470.1.17
MA0470.1.18
MA0470.1.19
MA0470.1.2
MA0470.1.20
MA0470.1.3
MA0470.1.4
MA0470.1.5
MA0470.1.6
MA0470.1.7
MA0470.1.8
MA0470.1.9
Publications: Xu X., Bieda M., Jin V. X., Rabinovich A., Oberley M. J., Green R., Farnham P. J. A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members.. Genome Res. 17:1550-1561 (2007). [Pubmed]

Rabinovich A, Jin VX, Rabinovich R, Xu X, Farnham PJ. E2F in vivo binding specificity: comparison of consensus versus nonconsensus binding sites. Genome Res 18:1763-77 (2008). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.