Transcription Factor

Accessions: MITF_HUMAN (HOCOMOCO 10), O75030 (JASPAR 2024)
Names: bHLHe32, Class E basic helix-loop-helix protein 32, Microphthalmia-associated transcription factor, MITF_HUMAN
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 526
Pfam Domains: 312-365 Helix-loop-helix DNA-binding domain
397-522 Domain of unknown function (DUF3371)
Sequence:
(in bold interface residues)
1 MQSESGIVPDFEVGEEFHEEPKTYYELKSQPLKSSSSAEHPGASKPPISSSSMTSRILLR 60
61 QQLMREQMQEQERREQQQKLQAAQFMQQRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQ 120
121 THLENPTKYHIQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNS 180
181 PMAMLTLNSNCEKEGFYKFEEQNRAESECPGMNTHSRASCMQMDDVIDDIISLESSYNEE 240
241 ILGLMDPALQMANTLPVSGNLIDLYGNQGLPPPGLTISNSCPANLPNIKRELTACIFPTE 300
301 SEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDY 360
361 IRKLQREQQRAKELENRQKKLEHANRHLLLRIQELEMQARAHGLSLIPSTGLCSPDLVNR 420
421 IIKQEPVLENCSQDLLQHHADLTCTTTLDLTDGTITFNNNLGTGTEANQAYSVPTKMGSK 480
481 LEDILMDDTLSPVGVTDPLLSSVSPGASKTSSRRSSMSMEETEHTC
Interface Residues: 313, 315, 316, 317, 319, 320, 323, 324, 348, 350
3D-footprint Homologues: 1a0a_B, 1an4_A, 4zpk_A, 7ssa_L, 6g1l_A, 5eyo_A, 7xi3_A, 5nj8_D, 4h10_A, 7d8t_A, 5gnj_I, 1am9_A, 8osl_O, 5v0l_A, 4h10_B, 7f2f_B, 5i50_B, 8osl_P, 2ypa_A, 5nj8_C, 5v0l_B
Binding Motifs: MITF_HUMAN.H10MO.C|M01330 rtCAtGTGmb
MA0620.2 wrwrGTCACGTGACywyw
MA0620.3 wwwrrTCACGTGAyywww
MA0620.4 rTCACGTGAy
Binding Sites: MA0620.2.1 / MA0620.3.19
MA0620.2.10
MA0620.2.11
MA0620.2.12
MA0620.2.13
MA0620.2.14
MA0620.2.15
MA0620.2.16
MA0620.2.17
MA0620.2.18
MA0620.2.19
MA0620.2.2 / MA0620.3.20
MA0620.2.20
MA0620.2.3
MA0620.2.4
MA0620.2.5
MA0620.2.6
MA0620.2.7
MA0620.2.8
MA0620.2.9
MA0620.3.1
MA0620.3.10
MA0620.3.11
MA0620.3.12
MA0620.3.13
MA0620.3.14
MA0620.3.13 / MA0620.3.15
MA0620.3.14 / MA0620.3.16
MA0620.3.15 / MA0620.3.17
MA0620.3.16 / MA0620.3.18
MA0620.3.17 / MA0620.3.19
MA0620.3.2
MA0620.3.18 / MA0620.3.20
MA0620.3.3
MA0620.3.4
MA0620.3.5
MA0620.3.6
MA0620.3.7
MA0620.3.8
MA0620.3.9
MA0620.4.6
MA0620.3.1
MA0620.3.2
MA0620.3.3
MA0620.3.4
MA0620.4.16
MA0620.4.5
MA0620.4.1
MA0620.4.10
MA0620.4.11
MA0620.4.12
MA0620.4.13
MA0620.4.14
MA0620.4.15
MA0620.4.17
MA0620.4.18
MA0620.4.19
MA0620.4.2
MA0620.4.20
MA0620.4.3
MA0620.4.4
MA0620.4.7
MA0620.4.8
MA0620.4.9
Publications: McGill G. G., Horstmann M., Widlund H. R., Du J., Motyckova G., Nishimura E. K., Lin Y. L., Ramaswamy S., Avery W., Ding H. F., Jordan S. A., Jackson I. J., Korsmeyer S. J., Golub T. R., Fisher D. E. Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability.. Cell 109:707-718 (2002). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.