Transcription Factor
| Accessions: | 1ram_A (3D-footprint 20231221), 1ram_B (3D-footprint 20231221), 5u01_A (3D-footprint 20231221), 5u01_B (3D-footprint 20231221), 5u01_C (3D-footprint 20231221), 5u01_D (3D-footprint 20231221) |
| Names: | Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, TF65_MOUSE, TRANSCRIPTION FACTOR NF-KB P65, Transcription factor p65 |
| Organisms: | Mus musculus |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | Q04207 |
| Length: | 273 |
| Pfam Domains: | 3-168 Rel homology domain (RHD) |
| Sequence: (in bold interface residues) | 1 PYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVT 60 61 KDPPHRPHPHELVGKDCRDGYYEADLCPDRSIHSFQNLGIQCVKKRDLEQAISQRIQTNN 120 121 NPFHVPIEEQRGDYDLNAVRLCFQVTVRDPAGRPLLLTPVLSHPIFDNRAPNTAELKICR 180 181 VNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYA 240 241 DPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPD |
| Interface Residues: | 15, 17, 18, 20, 21, 23, 24, 25, 117, 169, 171, 200, 228 |
| 3D-footprint Homologues: | 7cli_B, 1a3q_A, 1nfk_A, 1a66_A, 2o61_A, 1gji_A, 2ram_A, 1imh_C |
| Binding Motifs: | 1ram_AB amnTTCCA 5u01_ABCD CGGAAnTTCCCGGGAAnTTCCGC 5u01_C cGGGAa |
| Binding Sites: | 1ram_C / 1ram_D 5u01_E / 5u01_F |
| Publications: | Chen Y.Q, Ghosh S, Ghosh G. A novel DNA recognition mode by the NF-kappa B p65 homodimer. Nature structural biology 5:67-73 (1998). [Pubmed] Mulero MC, Huang DB, Nguyen HT, Wang V, Li Y, Biswas T, Ghosh G. DNA-binding affinity and transcriptional activity of the RelA homodimer of nuclear factor kappa B are not correlated. J Biol Chem : (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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