Transcription Factor

Accessions: P82976 (JASPAR 2024)
Names: Gastrulation and brain-specific homeobox protein 1, GBX1_MOUSE, Homeobox protein GBX-1
Organisms: Mus musculus
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P82976
Length: 418
Pfam Domains: 317-373 Homeobox domain
Sequence:
(in bold interface residues)
1 MSPEGDTPNPPARPLPPYERESAAPEPHCAEPAPRRHLGPRARSEPCVSARGARRGPGSA 60
61 MQRAAGGGAPGGSGGSSGGPGAAFSIDSLIGPPPPRSGHLLYTGYPMFMPYRPLVLPQAL 120
121 APAPLPAGLPPLAPLASFAGRLSNTFCAGLGQAVPSMVALTTALPSFAEPPDAYYGPPEL 180
181 AAAAASTASRSNPEPAARRTDGALDAEELLPAREKVTEPPPPPPPHFSETFPSLPAEGKV 240
241 YSSDEEKLEPPAGDPAGSEQEEEGSGGDSEDSFLDSSAGGPGALLGPKPKLKGSPGTGAE 300
301 EGTPVATGVTTPGGKSRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQV 360
361 KIWFQNRRAKWKRIKAGNVSSRSGEPVRNPKIVVPIPVHVNRFAVRSQHQQMEQGARP
Interface Residues: 317, 318, 319, 320, 321, 322, 358, 359, 361, 362, 365, 366, 369, 370, 373
3D-footprint Homologues: 1fjl_B, 5zfz_A, 1ig7_A, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 3d1n_M, 1nk2_P, 1zq3_P, 6m3d_C, 4j19_B, 3lnq_A, 2lkx_A, 1jgg_B, 2ld5_A, 1mnm_C, 7q3o_C, 6es3_K, 4cyc_A, 1b72_A, 5flv_I, 5zjt_E, 3a01_E, 7psx_B, 5hod_A, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 1au7_A, 4xrs_G, 2hos_A, 1le8_B, 1k61_B, 7xrc_C, 2xsd_C, 1le8_A, 1e3o_C, 3l1p_A, 1o4x_A, 8g87_X, 1du0_A, 4qtr_D
Binding Motifs: PH0033.1 wdsmaCYAATTRGtgbw
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

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