Transcription Factor
| Accessions: | O15499 (JASPAR 2024) |
| Names: | GSC-2, GSC-L, GSC2_HUMAN, Homeobox protein goosecoid-2, Homeobox protein goosecoid-like |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | O15499 |
| Length: | 205 |
| Pfam Domains: | 127-183 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MAAAAGGAASRRGAGRPCPFSIEHILSSLPERSLPARAACPPQPAGRQSPAKPEEPGAPE 60 61 AAPCACCCCCGPRAAPCGPPEAAAGLGARLAWPLRLGPAVPLSLGAPAGGSGALPGAVGP 120 121 GSQRRTRRHRTIFSEEQLQALEALFVQNQYPDVSTRERLAGRIRLREERVEVWFKNRRAK 180 181 WRHQKRASASARLLPGVKKSPKGSC |
| Interface Residues: | 102, 106, 125, 127, 128, 129, 130, 168, 169, 171, 172, 175, 176, 179, 180, 183 |
| 3D-footprint Homologues: | 1au7_A, 2lkx_A, 1fjl_B, 2h1k_B, 1puf_A, 1ig7_A, 6a8r_A, 3cmy_A, 3d1n_M, 5zfz_A, 3lnq_A, 1jgg_B, 1nk2_P, 1zq3_P, 2ld5_A, 1le8_B, 7q3o_C, 6es3_K, 1k61_B, 5zjt_E, 4j19_B, 3a01_E, 7psx_B, 1b72_A, 5hod_A, 2hdd_A, 1mnm_C, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 4xrs_G, 2hos_A, 4cyc_A, 6m3d_C, 5flv_I, 7xrc_C, 1e3o_C, 2xsd_C, 3l1p_A, 1o4x_A, 8g87_X, 4qtr_D, 1du0_A |
| Binding Motifs: | MA0891.1 cyTAATCcsh MA0891.2 TAATCc |
| Publications: | Funke B, Saint-Jore B, Puech A, Sirotkin H, Edelmann L, Carlson C, Raft S, Pandita RK, Kucherlapati R, Skoultchi A, Morrow BE. Characterization and mutation analysis of goosecoid-like (GSCL), a homeodomain-containing gene that maps to the critical region for VCFS/DGS on 22q11. Genomics 46:364-72 (1997). [Pubmed] |
| Related annotations: | PaperBLAST |
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