Transcription Factor

Accessions: br-Z1 (DrosophilaTF 1.1), T000288_1.02 (CISBP 1.02), Q01295 (JASPAR 2024)
Names: BRC1_DROME, T000288_1.02;
Organisms: Drosophila melanogaster
Libraries: DrosophilaTF 1.1 1, CISBP 1.02 2, JASPAR 2024 3
1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed]
2 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: family:ABF1,C2H2 ZF
Length: 727
Pfam Domains: 22-121 BTB/POZ domain
636-659 C2H2-type zinc finger
668-685 C2H2-type zinc finger
Sequence:
(in bold interface residues)
1 MDDTQHFCLRWNNYQSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFREL 60
61 LKSTPCKHPVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEVLRVSGLTQQQA 120
121 EDTHSHLAQIQNLANSGGRTPLNTHTQSLPHPHHGSLHDDGGSSTLFSRQGAGSPPPTAV 180
181 PSLPSHINNQLLKRMAMMHRSSAAAAAEETSHAFKRLRGSDNSLPLSGAVGSGSNNNSPD 240
241 LPPLHARSASPQQTPADFSTIKHHNNNNTPPLKEEKRNGPTGNGNSGNGNGNGNGASNGN 300
301 GISISDKLGSLTPSPLARAGADDVKSEPMDMVCSNNNANANDEHSNDSTGEHDANRSSSG 360
361 DGGKGSLSSGNDEEIGDGLASHHAAPQFIMSPAENKMFHAAAFNFPNIDPSALLGLNTQL 420
421 QQSGDLAVSPQGKLTTNATTTTTTINNSITNNNNNNNNNNYDYSLPTKNSNSQKTPSPTT 480
481 TTLTTPTTTTPTRPTAITSASGICGLNLSTFAANGSSSGGSNGGLSMTALLPQQQQQQQQ 540
541 QHQMSQQQQQQQQQQQQQGNSSSGQQQQPNGILACSTPKANTPTTTQQQMYAAVMAAAAS 600
601 ASASTSGSANSSLNNSNSTLNTSGGLNNSASGGDDFRCNPCNKNLSSLTRLKRHIQNVHM 660
661 RPTKEPVCNICKRVYSSLNSLRNHKSIYHRNLKQPKQEPGVGATQAAANSFYHQQHQQQQ 720
721 LNHHSSS
Interface Residues: 646, 647, 648, 649, 650, 651, 652, 653, 657, 658, 676, 677, 678, 679, 680, 682, 683
3D-footprint Homologues: 7ysf_A, 1g2f_F, 8cuc_F, 6ml4_A, 6u9q_A, 2drp_D, 5yel_A, 6e94_A, 4x9j_A, 1llm_D, 5v3j_F, 2lt7_A
Binding Motifs: br-Z1 TAAwwrACAArw
M2533_1.02 wwrtaAwwrACAArwcwm
MA0010.1 rtaAwwrACAArwc
MA0011.1 wwCTAtTt
MA0012.1 wAAACwArwhs
MA0010.2 taAwwrACAArw
MA0011.2 CTAtTt
MA0012.2 wAAACwAr
Binding Sites: MA0012.2.8
MA0010.1.1
MA0010.1.2
MA0010.1.3
MA0010.1.4
MA0010.1.5
MA0010.1.6
MA0010.1.7
MA0010.1.8
MA0010.1.9
MA0011.1.1
MA0011.1.10
MA0011.1.11
MA0011.1.12
MA0011.1.2
MA0011.1.3
MA0011.1.4
MA0011.1.5
MA0011.1.6
MA0011.1.7
MA0011.1.8
MA0011.1.9
MA0012.1.1
MA0012.1.10
MA0012.1.11
MA0012.1.12
MA0012.1.2
MA0012.1.3
MA0012.1.4
MA0012.1.5
MA0012.1.6
MA0012.1.7
MA0012.1.8
MA0012.1.9
MA0010.2.1
MA0010.2.2 / MA0010.2.6
MA0010.2.3
MA0010.2.4
MA0010.2.5
MA0010.2.7
MA0010.2.8
MA0010.2.9
MA0011.2.1
MA0011.2.10
MA0011.2.11 / MA0011.2.12
MA0011.2.2
MA0011.2.3
MA0011.2.4
MA0011.2.5
MA0011.2.6
MA0011.2.7
MA0011.2.8
MA0011.2.9
MA0012.2.1
MA0012.2.10
MA0012.2.11
MA0012.2.12
MA0012.2.2
MA0012.2.3
MA0012.2.4 / MA0012.2.7
MA0012.2.5
MA0012.2.6
MA0012.2.9
Publications: von Kalm L., Crossgrove K., Von Seggern D., Guild G. M., Beckendorf S. K. The Broad-Complex directly controls a tissue-specific response to the steroid hormone ecdysone at the onset of Drosophila metamorphosis. EMBO J. 13:3505-3516 (1994). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.